{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:25:32Z","timestamp":1793708732203,"version":"4.6.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Emergency management project of the National Natural Science Foundation of China","award":["31741094"],"award-info":[{"award-number":["31741094"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1177\/1933719118820466","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T03:56:02Z","timestamp":1546401362000},"page":"1439-1448","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF\/ICSI"],"prefix":"10.1007","volume":"26","author":[{"given":"Jun","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Pu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"issue":"1","key":"2601104_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5694\/mja11.10553","volume":"196","author":"JA Boyle","year":"2012","unstructured":"Boyle JA, Cunningham J, O'Dea K, Dunbar T, Norman RJ. Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia. Med J Aust. 2012;196(1): 62\u201366.","journal-title":"Med J Aust."},{"issue":"10","key":"2601104_CR2","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/humrep\/des232","volume":"27","author":"BO Yildiz","year":"2012","unstructured":"Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. Prevalence, phenotype and cardiometabolic risk ofpolycystic ovary syndrome under different diagnostic criteria. Hum Reprod. 2012;27(10): 3067\u20133073.","journal-title":"Hum Reprod."},{"issue":"6","key":"2601104_CR3","first-page":"3073","volume":"39","author":"Y Yang","year":"2018","unstructured":"Yang Y, Jiang H, Xiao L, Yang X. MicroRNA-33b-5p is over-expressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: an in vivo and in vitro study. Oncol Rep. 2018;39(6):3073\u20133085.","journal-title":"Oncol Rep."},{"issue":"5","key":"2601104_CR4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1210\/er.2015-1104","volume":"37","author":"RL Rosenfield","year":"2016","unstructured":"Rosenfield RL, Ehrmann DA. The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocrine Rev. 2016;37(5): 467\u2013520.","journal-title":"Endocrine Rev."},{"issue":"6","key":"2601104_CR5","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1210\/er.2011-1034","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","unstructured":"Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Rev. 2012;33(6):981\u20131030.","journal-title":"Endocrine Rev."},{"issue":"1","key":"2601104_CR6","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/ajd.12276","volume":"57","author":"S Bonakdaran","year":"2016","unstructured":"Bonakdaran S, Kiafar B, Barazandeh Ahmadabadi F. Evaluation of insulin resistance in idiopathic hirsutism compared with poly-cystic ovary syndrome patients and healthy individuals. Aust J Dermatol. 2016;57(1):e1\u2013e4.","journal-title":"Aust J Dermatol."},{"issue":"1","key":"2601104_CR7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/1933719114561552","volume":"22","author":"MM Schulte","year":"2015","unstructured":"Schulte MM, Tsai JH, Moley KH. Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. Reprod Sci. 2015;22(1):6\u201314.","journal-title":"Reprod Sci."},{"issue":"2","key":"2601104_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1095\/biolreprod.112.099788","volume":"87","author":"J Zhai","year":"2012","unstructured":"Zhai J, Liu C, Tian Z, Jiang Q, Sun Y. Effects of metformin on the expression of GLUT4 in endometrium of obese women with poly-cystic ovary syndrome. Biol Reprod. 2012;87(2):29.","journal-title":"Biol Reprod."},{"issue":"3","key":"2601104_CR9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ygyno.2014.01.004","volume":"132","author":"W Shan","year":"2014","unstructured":"Shan W, Ning C, Luo X, et al. Hyperinsulinemia is associated with endometrial hyperplasia and disordered proliferative endo-metrium: a prospective cross-sectional study. Gynecol Oncol. 2014;132(3):606\u2013610.","journal-title":"Gynecol Oncol."},{"issue":"1","key":"2601104_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijgo.2014.10.022","volume":"129","author":"MC Baracat","year":"2015","unstructured":"Baracat MC, Serafini PC, Simoes RS, Maciel GA, Soares JM Jr, Baracat EC. Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome. Int J Gynaecol Obstet. 2015;129(1): 1\u20134.","journal-title":"Int J Gynaecol Obstet."},{"key":"2601104_CR11","first-page":"CD006105","volume":"11","author":"L Tso","year":"2014","unstructured":"Tso L, Costello M, Albuquerque L, et al. Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2014;(11):CD006105.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"2601104_CR12","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI1597","volume":"101","author":"A Taylor H S, Arici","year":"1998","unstructured":"Taylor H S, Arici A, Olive D, et al. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101(7):1379\u20131384.","journal-title":"J Clin Invest."},{"issue":"1","key":"2601104_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1210\/jc.2002-021072","volume":"88","author":"D Cermik","year":"2003","unstructured":"Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome. JClin Endocrinol Metab. 2003;88(1):238\u2013243.","journal-title":"JClin Endocrinol Metab."},{"issue":"3","key":"2601104_CR14","first-page":"571","volume":"16","author":"GS Daftary","year":"2002","unstructured":"Daftary GS, Troy PJ, Bagot CN, Taylor HS. Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endome- trial cells. Mol Endocrinol. 2002;16(3):571\u2013579.","journal-title":"Mol Endocrinol."},{"issue":"12","key":"2601104_CR15","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1210\/jc.2011-1231","volume":"96","author":"R Petracco","year":"2011","unstructured":"Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 regulates HOXA10 expression in endometriosis. J Clin Endocrinol Metabol. 2011;96(12): 1925\u20131933.","journal-title":"J Clin Endocrinol Metabol."},{"issue":"1","key":"2601104_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.fertnstert.2011.04.072","volume":"96","author":"AG Sha","year":"2011","unstructured":"Sha AG, Liu JL, Jiang XM, et al. Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing. Fertil Steril. 2011;96(1):150\u2013155.","journal-title":"Fertil Steril."},{"issue":"9","key":"2601104_CR17","doi-asserted-by":"publisher","first-page":"e12970","DOI":"10.1371\/journal.pone.0012970","volume":"5","author":"NM Kane","year":"2010","unstructured":"Kane NM, Jones M, Brosens JJ, Kelly RW, Saunders PT, Critch-ley HO. TGF\u03b21 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways. PLoS One. 2010;5(9):e12970.","journal-title":"PLoS One."},{"issue":"10","key":"2601104_CR18","first-page":"991","volume":"6","author":"Z Bu","year":"2013","unstructured":"Bu Z, Dai W, Guo Y, Su Y, Zhai J, Sun Y. Overweight and obesity adversely affect outcomes of assisted reproductive technologies in polycystic ovary syndrome patients. Int J Clin Exp Med. 2013;6(10):991\u2013995.","journal-title":"Int J Clin Exp Med."},{"issue":"8","key":"2601104_CR19","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.1007\/s13277-014-1970-5","volume":"35","author":"L Liu","year":"2014","unstructured":"Liu L, Zou J, Wang Q, Yin FQ, Zhang W, Li L. Novel micro-RNAs expression of patients with chemotherapy drug-resistant and chemotherapy-sensitive epithelial ovarian cancer. Tumor Biol. 2014;35(8):7713\u20137717.","journal-title":"Tumor Biol."},{"issue":"3","key":"2601104_CR20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nrg1808","volume":"7","author":"H Wang","year":"2006","unstructured":"Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet. 2006;7(3):185\u2013199.","journal-title":"Nat Rev Genet."},{"issue":"9","key":"2601104_CR21","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1007\/s00125-017-4351-y","volume":"60","author":"RS Lindsay","year":"2017","unstructured":"Lindsay RS, Loeken MR. Metformin use in pregnancy: promises and uncertainties. Diabetologia. 2017;60(9):1612\u20131619.","journal-title":"Diabetologia."},{"issue":"suppl3","key":"2601104_CR22","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/humrep\/13.suppl_3.247","volume":"13","author":"BA Lessey","year":"1998","unstructured":"Lessey BA. Endometrial integrins and the establishment of uterine receptivity. Hum Reprod. 1998;13(suppl 3):247\u2013258.","journal-title":"Hum Reprod."},{"issue":"7","key":"2601104_CR23","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.placenta.2008.04.006","volume":"29","author":"P Murthi","year":"2008","unstructured":"Murthi P, Hiden U, Rajaraman G. Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells. Placenta. 2008;29(7): 624\u2013630.","journal-title":"Placenta."},{"key":"2601104_CR24","first-page":"34","volume":"2","author":"J Kim","year":"2004","unstructured":"Kim J, Fazleabas A. Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. Reprod Biol Endocrinol. 2004;2:34.","journal-title":"Reprod Biol"},{"issue":"5","key":"2601104_CR25","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.18632\/oncotarget.3063","volume":"6","author":"X Jiang","year":"2015","unstructured":"Jiang X, Ma N, Wang D, et al. Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma. Oncotarget. 2015;6(5):3178\u20133194.","journal-title":"Oncotarget."},{"issue":"5","key":"2601104_CR26","doi-asserted-by":"publisher","first-page":"e0125779","DOI":"10.1371\/journal.pone.0125779","volume":"10","author":"R Tanaka","year":"2015","unstructured":"Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T. Metfor-min causes G1-phase arrest via down-regulation of MiR-221 and enhances TRAIL sensitivity through DR5 up-regulation in pancreatic cancer cells. PLoS One. 2015;10(5):e0125779.","journal-title":"PLoS One."},{"issue":"3","key":"2601104_CR27","first-page":"574","volume":"7","author":"X Li","year":"2015","unstructured":"Li X, Cui P, Jiang HY, et al. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. Am J Translational Res. 2015;7(3):574\u2013586.","journal-title":"Am J Translational Res."},{"issue":"12","key":"2601104_CR28","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.7150\/ijbs.16529","volume":"12","author":"Y Zhang","year":"2016","unstructured":"Zhang Yajie, Xu Wenxia, Ni Pan, et al. MiR-99a and MiR-491 regulate cisplatin resistance in human gastric cancer cells by targeting CAPNS1. Int J Biol Sci. 2016;12(12):1437\u20131447.","journal-title":"Int J Biol Sci."},{"issue":"1","key":"2601104_CR29","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12883-016-0769-y","volume":"16","author":"Z Qi","year":"2016","unstructured":"Qi Z, Cai S, Cai J, et al. miR-491 regulates glioma cells proliferation by targeting TRIM28 in vitro. BMC Neurol. 2016;16(1):248.","journal-title":"BMC Neurol."},{"issue":"1","key":"2601104_CR30","volume":"50","year":"2017","unstructured":"Yin Z, Ding H, He E, Chen J, Li M. Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 inhuman osteosarcoma. CellProlif. 2017;50(1).","journal-title":"CellProlif."},{"issue":"2","key":"2601104_CR31","first-page":"485","volume":"8","author":"F Gong","year":"2016","unstructured":"Gong F, Ren P, Zhang Y, Jiang J, Zhang H. MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer. Am J Transl Res. 2016;8(2): 485\u2013495.","journal-title":"Am J Transl Res."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719118820466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719118820466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719118820466\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719118820466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719118820466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T02:14:14Z","timestamp":1656814454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719118820466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["2601104"],"URL":"https:\/\/doi.org\/10.1177\/1933719118820466","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"25 February 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}