{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:37:44Z","timestamp":1788453464636,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Preeclampsia (PE) is among the causes of serious morbidity and mortality for the mother and fetus. The most common consequences of intrauterine hypoxemia in the newborn are intrauterine growth retardation (IUGR), premature labor, respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), and perinatal death. The systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI), which is used as an indicator of inflammation, can be used to examine the effect of the immune status of babies of PE mothers on their prognosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : A retrospective cohort study was conducted on 148 newborns of PE mothers who received treatment in our NICU between November 2022 and July 2024. Hematological indices including neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, SII, and PNI were calculated for all patients. Subgroups were created for complications and analyses were performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : For all preeclamptic mothers\u2019 babies, the mean SII and PNI were 387.69 \u00b1 348.13 and 49.08 \u00b1 7.59, respectively. The SII for prematurity produced an area under the curveReceiver operating characteristic (ROC) of 0.76 (0.59\u20130.92) (88.4% sensitivity, 70% specificity). The PNI for prematurity produced an area under the curve ROC of 0.72 (0.57\u20130.86) (63% sensitivity, 70% specificity). That was found that the SII has more sensitivity than the PNI for detecting prematurity in preeclamptic mothers\u2019 babies. Low PNI and SII were independent predictors of mortality (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : We found that it is significant for SII and NLR to be low at the time of admission to predict mortality in infants of preeclamptic mothers.\n                  <\/jats:p>","DOI":"10.1177\/19345798251318599","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T19:11:56Z","timestamp":1738869116000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive values of prognostic nutritional index and systemic imm\u00fcne- inflammatory index in the follow-up newborns of preeclamptic mothers"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6144-4225","authenticated-orcid":false,"given":"Seda","family":"Aydo\u011fan","sequence":"first","affiliation":[{"name":"Department of Neonatology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-4804","authenticated-orcid":false,"given":"Caner","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1970-3247","authenticated-orcid":false,"given":"Eda","family":"T\u00fcfek\u00e7io\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-0082","authenticated-orcid":false,"given":"Meltem","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-1496","authenticated-orcid":false,"given":"Hasan","family":"Akduman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferit","family":"Kulal\u0131","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara Etlik City Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103780"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-07107-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122001202"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13806"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.09.007"},{"issue":"1","key":"e_1_3_3_9_2","first-page":"214365","article-title":"Maternal preeclampsia and neonatal outcomes","volume":"2011","author":"Backes CH","year":"2011","unstructured":"Backes CH, Markham K, Moorehead P, et al. Maternal preeclampsia and neonatal outcomes. J pregnancy 2011; 2011(1): 214365.","journal-title":"J pregnancy"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01864"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.973271"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S168569"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1297411"},{"issue":"4","key":"e_1_3_3_14_2","first-page":"BE01","article-title":"Role of biomarkers in early detection of preeclampsia","volume":"8","author":"Kar M","year":"2014","unstructured":"Kar M. Role of biomarkers in early detection of preeclampsia. J Clin Diagn Res 2014; 8(4): BE01\u2013BE04.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.02.003"},{"issue":"3","key":"e_1_3_3_16_2","first-page":"308","article-title":"Second-trimester maternal serum screening biomarkers in the risk assessment for preeclampsia","volume":"48","author":"Long W","year":"2018","unstructured":"Long W, Zhou Q, Wang H, et al. Second-trimester maternal serum screening biomarkers in the risk assessment for preeclampsia. Ann Clin Lab Sci 2018; 48(3): 308\u2013313.","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.04.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2024.02.011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02199-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2021.01.006"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.050"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-5276.22.06714-3"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02103-1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1410701"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251318599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251318599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251318599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:45Z","timestamp":1777588005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251318599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/19345798251318599"],"URL":"https:\/\/doi.org\/10.1177\/19345798251318599","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}