{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:10Z","timestamp":1777876570830,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jinrei-kai Association Community Healthcare Research Grant"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colonization of extended-spectrum beta-lactamase (ESBL)-producing organisms is increasing becoming more frequent not only in hospitalized patients but also in healthy individuals. Although these bacteria are thought to be transmitted to newborns on their way through the birth canal, molecular evidence for this is scarce. In this study, we aimed to survey the current prevalence of resistant bacterial colonization in this area by examining the colonization carriage of this organism before and after delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined the colonization rate of ESBL-producing bacteria in healthy pregnant women, the colonization rate in newborns, and the transmission rate from pregnant women who are carriers of the bacteria to their newborns. We also performed resistance gene and similarity analyses for each strain in pairs of mother-child carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 494 pregnant women, 33 carried ESBL-producing bacteria, all of whom were identified as Escherichia coli. The colonization carriage rate among pregnant women was 6.7%. Among newborns, the rate rose from 1.0% immediately after birth to 6.9% at the one-month checkup. Furthermore, of the 13 strains detected among mothers and children, 10 pairs had matching resistance genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Some ESBL-producing bacterial carriers exist even among healthy pregnant women, and about half of them go on to infect their newborns. However, routes of transmission beyond vertical transmission cannot be ruled out. Therefore, it is important to promote infection control in the healthcare environment and in the families of newborns, as well as antimicrobial stewardship among pregnant women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251318610","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T10:37:10Z","timestamp":1743244630000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Colonization of extended-spectrum beta-lactamase-producing bacteria in healthy pregnant women and its impact on perinatal care: A cross-sectional study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4798-0546","authenticated-orcid":false,"given":"Shigekatsu","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Fuchu Hospital, Izumi City, Japan"},{"name":"Department of Human Health and Medical Sciences, Hospital Administration Section, Kochi Medical School, Nankoku City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamae","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Imada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misato","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemi","family":"Okusa","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fuchu Hospital, Izumi City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Human Health and Medical Sciences, Hospital Administration Section, Kochi Medical School, Nankoku City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. Global action plan on antimicrobial resistance. https:\/\/www.who.int\/publications\/i\/item\/9789241509763"},{"key":"e_1_3_4_3_2","unstructured":"Ministry of Health Labour and Welfare. https:\/\/www.mhlw.go.jp\/file\/06Seisakujouhou-10900000-Kenkoukyoku\/0000138942.pdf"},{"key":"e_1_3_4_4_2","unstructured":"Ministry of Health Labour and Welfare. Drug resistant (AMR) one health trend survey annual report 2021. https:\/\/www.mhlw.go.jp\/content\/10900000\/001098919.pdf"},{"key":"e_1_3_4_5_2","unstructured":"Ministry of Health Labour and Welfare. Annual open report 2021 (All facilities) Japan nosocomial infections surveillance (JANIS) clinical laboratory division 5. Number of patients and isolation rate of specific AMR bacteria. https:\/\/janis.mhlw.go.jp\/english\/report\/open_report\/2021\/3\/1\/ken_Open_Report_Eng_202100_clsi2012.pdf"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02929-15"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.020"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.06.010"},{"key":"e_1_3_4_9_2","first-page":"661","article-title":"Shift in detection rate of extended-spectrum beta-lactamase (ESBL) producing strains within a three-year process of vaginal bacterial cultivation","volume":"53","author":"Nagae S","year":"2016","unstructured":"Nagae S, Aoki H, Izumi A, et al. Shift in detection rate of extended-spectrum beta-lactamase (ESBL) producing strains within a three-year process of vaginal bacterial cultivation. Kanto Journal of Obstetrics and Gynecology 2016; 53: 661\u2013665.","journal-title":"Kanto Journal of Obstetrics and Gynecology"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002623"},{"key":"e_1_3_4_11_2","first-page":"44","volume-title":"Performance Standards for antimicrobial susceptibility testing; twenty-second informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for antimicrobial susceptibility testing; twenty-second informational supplement. Wayne, PA: Clinical and Laboratory Standards Institute; 2012, pp. 44\u201349."},{"key":"e_1_3_4_12_2","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for antimicrobial susceptibility testing; twenty-second informational supplement. Wayne PA: Clinical and Laboratory Standards Institute pp. 50\u201351."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2015.1954"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3358\/shokueishi.58.1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.11.004"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2015.05.002"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0214-x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01862-w"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0498-0"},{"key":"e_1_3_4_21_2","first-page":"540","article-title":"Clustered cases of infections due to an uncommon methicillin-resistant Staphylococcus aureus originating in a maternity ward","volume":"51","author":"M\u00e9nard G","year":"2021","unstructured":"M\u00e9nard G, Morin-Le Bihan A, Isly H, et al. Clustered cases of infections due to an uncommon methicillin-resistant Staphylococcus aureus originating in a maternity ward. Infect Dis 2021; 51: 540.","journal-title":"Infect Dis"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251318610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251318610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251318610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:46Z","timestamp":1777588006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251318610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/19345798251318610"],"URL":"https:\/\/doi.org\/10.1177\/19345798251318610","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}