{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:12Z","timestamp":1777876572755,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background<\/jats:title>\n \n Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition resulting from elevated pulmonary vascular resistance, causing severe hypoxemia. Magnesium sulfate (MgSO\n 4<\/jats:sub>\n ) is a potent vasodilator used in PPHN treatment, but its intravenous administration can cause systemic side effects. This study aims to compare the effects of nebulized and intravenous MgSO\n 4<\/jats:sub>\n on oxygenation and hemodynamic parameters in neonates with severe PPHN.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This non-randomized controlled study was conducted on 40 mechanically ventilated neonates with severe PPHN at Benha University Hospitals. Neonates were divided into two groups: one received nebulized MgSO\n 4<\/jats:sub>\n (NebMag,\n n<\/jats:italic>\n = 20) and the other intravenous MgSO\n 4<\/jats:sub>\n (IVMag,\n n<\/jats:italic>\n = 20). Primary outcome was the change in Oxygenation Index (OI) at 12 and 24\u00a0hours. Secondary outcomes included changes in mean arterial pressure (MABP), serum magnesium levels, and vasoactive inotropic score (VIS).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both groups showed improvements in oxygenation and ventilatory parameters. However, after 24\u00a0hours, the NebMag group had significantly lower OI (19.75 \u00b1 2.9 vs 22.1 \u00b1 2.19,\n p<\/jats:italic>\n = 0.032) and higher PaO\n 2<\/jats:sub>\n (69.45 \u00b1 7.56\u00a0mmHg vs 60.75 \u00b1 5.9\u00a0mmHg,\n p<\/jats:italic>\n = 0.008). MABP was significantly higher and VIS was lower in the NebMag group at all time points. Serum magnesium levels were significantly lower in the NebMag group at 12\u00a0hours (3.6 \u00b1 0.18 vs 1.2 \u00b1 0.17\u00a0mmol\/L,\n p<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Nebulized MgSO\n 4<\/jats:sub>\n may offer a safer alternative to intravenous administration, providing effective pulmonary vasodilation with fewer systemic side effects in neonates with PPHN.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/19345798251325510","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:29:54Z","timestamp":1741926594000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative study between nebulized and intravenous magnesium sulfate for treatment of persistent pulmonary hypertension in neonates"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-9216","authenticated-orcid":false,"given":"Nashwa Farouk","family":"Mohamed","sequence":"first","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama Abu El Fetouh","family":"Zaki El Feky","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba Morsy","family":"Saad El Din El Ganady","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid Abd Elatif","family":"Abd El Halim","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13051"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00342"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.03.004"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03643-y"},{"issue":"3","key":"e_1_3_5_6_2","first-page":"Cd005588","article-title":"Magnesium sulfate for persistent pulmonary hypertension of the newborn","volume":"2007","author":"Ho JJ","year":"2007","unstructured":"Ho JJ, Rasa G. Magnesium sulfate for persistent pulmonary hypertension of the newborn. Cochrane Database Syst Rev 2007; 2007(3): Cd005588.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0973217921999383"},{"issue":"1","key":"e_1_3_5_8_2","first-page":"1","article-title":"Inhalational versus intravenous magnesium sulfate in management of pulmonary hypertension in neonates","volume":"24","author":"Abdalsalam AA","year":"2019","unstructured":"Abdalsalam AA, Hadhood S, El-Aal A, et al. Inhalational versus intravenous magnesium sulfate in management of pulmonary hypertension in neonates. Sohag Med J 2019; 24(1): 1\u201313.","journal-title":"Sohag Med J"},{"issue":"10","key":"e_1_3_5_9_2","first-page":"1266","article-title":"Role of magnesium sulphate in treatment of severe persistent pulmonary hypertension of the newborn","volume":"23","author":"Daffa SH","year":"2002","unstructured":"Daffa SH, Milaat WA. Role of magnesium sulphate in treatment of severe persistent pulmonary hypertension of the newborn. Saudi Med J 2002; 23(10): 1266\u20131269.","journal-title":"Saudi Med J"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.4.219"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.35702\/neo.10013"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-83434-0_65"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq091"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05803"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251325510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251325510","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251325510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:49Z","timestamp":1777588009000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251325510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/19345798251325510"],"URL":"https:\/\/doi.org\/10.1177\/19345798251325510","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]}}}