{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:14Z","timestamp":1777876574182,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal respiratory distress is a major issue for many infants. When non-invasive ventilation fails, endotracheal intubation is often used to secure the airway. However, extubation moving from mechanical ventilation to spontaneous breathing also has its challenges and risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomized controlled trial aimed to compare neonatal outcomes between positive- and negative-pressure extubation methods in a cohort of neonates ready for extubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial was conducted at Ayatollah Taleghani Hospital in Ilam, Iran, from May 2021 to March 2023; the study enrolled 101 neonates, who were divided into three groups: positive pressure, negative pressure, and self-extubation. Neonates with congenital respiratory defects, meconium aspiration, and bacterial pneumonia were excluded from the study. The primary outcomes assessed included the duration of intubation, need for oxygen post-extubation, and length of hospitalization. Statistical analysis was performed using the independent-samples Kruskal-Wallis test, with a significance level set at\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences were found in the duration of intubation (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.436), need for oxygen after extubation (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.785), and length of hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.357) among the groups. There was a significant difference in the duration of intubation, need for oxygen after extubation, and length of hospital stay based on gestational age at birth (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000). However, there was no significant correlation between age at birth and re-intubation (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.297).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There are no significant differences in key outcomes like intubation duration, post-extubation oxygen needs, and hospitalization length, suggesting that the choice of extubation method may not greatly affect these factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251330807","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T14:22:03Z","timestamp":1743517323000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing neonatal outcomes of positive- versus negative-pressure extubation: A randomized trial"],"prefix":"10.1177","volume":"18","author":[{"given":"S","family":"Nourolahi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran"},{"name":"Ayatollah Taleghani Hospital, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Solimani","sequence":"additional","affiliation":[{"name":"Ayatollah Taleghani Hospital, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Direkvand-Moghadam","sequence":"additional","affiliation":[{"name":"Ayatollah Taleghani Hospital, Ilam University of Medical Sciences, Ilam, Iran"},{"name":"Department of Midwifery, School of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0112-2024"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.56294\/sctconf2024944"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27265"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2024.151890"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-36510-2_2"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.11193"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.7269"},{"issue":"2","key":"e_1_3_6_9_2","first-page":"e53558","article-title":"A comprehensive review of inhaled nitric oxide therapy: current trends, challenges, and future directions","volume":"16","author":"Kaplish D","year":"2024","unstructured":"Kaplish D, Vagha JD, Meshram RJ, et al. 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