{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:14:29Z","timestamp":1784290469498,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5\u00a0minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of clefts was 7.1\/10,000 in the United States and 6.2\/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), be premature (PR = 1.37,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), be born by cesarean section (PR = 1.00,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), and have low birth weight (PR = 1.49,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000). Their mothers tended to be older (PR = 1.09,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), non-white (PR = 0.48,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), compared to the United States cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals\u2019 susceptibility to risk factors for clefts and poor birth health conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251343829","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:15:38Z","timestamp":1747307738000},"page":"526-532","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative study of individuals born with orofacial clefts in the United States and Brazil"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6970","authenticated-orcid":false,"given":"Adriana M","family":"da Silva","sequence":"first","affiliation":[{"name":"Department of Health, State University of Feira de Santana, Feira de Santana, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VS","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health, State University of Feira de Santana, Feira de Santana, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AR","family":"Vieira","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(03)00138-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejwf.2020.09.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","unstructured":"Dixon MJ Marazita ML Beaty TH et al. Cleft lip and palate: synthesizing genetic and environmental influences. NIH Public Access 2011; 3(3): 203 Dispon\u00edvel em: https:\/\/bibliotecadigital.icesi.edu.co\/biblioteca_digital\/bitstream\/item\/5291\/5\/Politicas_Pyme_volumen3.pdf. DOI: 10.1038\/nrg2933.Cleft.","DOI":"10.1038\/nrg2933.Cleft"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/children9121846"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1830"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-23018"},{"key":"e_1_3_3_8_2","volume-title":"Social Determinants of Health","author":"Pan American Health Association(PAHO), World Health Organization (WHO)","year":"2022","unstructured":"Pan American Health Association(PAHO), World Health Organization (WHO). Social Determinants of Health. 2022. [citado 15 de janeiro de 2022]. Dispon\u00edvel em: https:\/\/www.paho.org\/en\/topics\/social-determinants-health#:\u223c:text=TheSocialDeterminantsofHealth,theconditionsofdailylife"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-3163-5_2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0370_papfaw_2.0.co_2"},{"key":"e_1_3_3_11_2","unstructured":"Pittsburgh orofacial cleft studies 2022. Dispon\u00edvel em: https:\/\/www.dental.pitt.edu\/research\/ccdg\/participate-research\/pittsburgh-orofacial-cleft-studies"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/2024\/42\/2022234"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","unstructured":"Card EB Morales CE Kimia R et al. A retrospective and prospective cohort study comparing pediatric patients with cleft lip and palate from the United States and Guatemala. J Craniofac Surg. 14 de julho de 2023; Dispon\u00edvel em: DOI: 10.1097\/SCS.0000000000009539.","DOI":"10.1097\/SCS.0000000000009539"},{"key":"e_1_3_3_14_2","unstructured":"Center for Disease Control - CDC. User Guide to the 2021 natality public use file."},{"key":"e_1_3_3_15_2","unstructured":"Minist\u00e9rio da Sa\u00fade. Declara\u00e7\u00e3o de Nascido Vivo Manual de instru\u00e7\u00f5es para preenchimento. [Internet]. Dispon\u00edvel em: https:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/declaracao_nascido_vivo_manual_4ed.pdf"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.5123\/s1679-49742015000400005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2007000300028"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2021.05.008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1589.National"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337464"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2008.02.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.20396\/bjos.v22i00.8669246"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes8060150"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2021.108373"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000008636"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.5937\/afmnai1902102l"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017063"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656231180086"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2018.vol32.0024"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656231204503"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_673_17"},{"key":"e_1_3_3_32_2","first-page":"318","volume-title":"Aten\u00e7\u00e3o ao pr\u00e9-natal de baixo risco","author":"Minist\u00e9rio da Sa\u00fade","year":"2013","unstructured":"Minist\u00e9rio da Sa\u00fade. Aten\u00e7\u00e3o ao pr\u00e9-natal de baixo risco. 32nd ed. Brasilia: Minist\u00e9rio da Sa\u00fade, Organizador, 2013, p. 318. Dispon\u00edvel em: https:\/\/www.saude.gov.br\/dab","edition":"32"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20211239"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2015-0364"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005671"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058690"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015402"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211002148"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656211018952"},{"key":"e_1_3_3_41_2","first-page":"432","article-title":"How Low Socioeconomic Status during Pregnancy Causes Orofacial Clefts in Newborns","volume":"15","author":"Nehra RA","year":"2021","unstructured":"Nehra RA, Riasat Nahra A, Gulzar A, et al. How Low Socioeconomic Status during Pregnancy Causes Orofacial Clefts in Newborns. PJMHS 2021; 15: 432\u2013433. https:\/\/pjmhsonline.com\/2021\/feb\/432.pdf.","journal-title":"PJMHS"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251343829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251343829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251343829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:59Z","timestamp":1777588019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251343829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/19345798251343829"],"URL":"https:\/\/doi.org\/10.1177\/19345798251343829","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}