{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:00:30Z","timestamp":1787238030791,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal jaundice affects 60% of term and 80% of preterm newborns due to high levels of unconjugated bilirubin, leading to significant health issues. Currently, probiotics were used as a promising agent to enhance phototherapy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this systematic review is to assess the effect of probiotics supplementation in neonatal jaundice therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four reviewers extracted randomized controlled trial (RCT) studies from Google Scholar, PubMed, and the Cochrane Library as per PRISMA guidelines. The risk of bias will be assessed using the Cochrane risk of bias tool for randomized trials (RoB 2). Inclusion criteria comprised term or preterm neonates diagnosed with any type of jaundice warranting phototherapy, outcome comparison between probiotic supplementation in phototherapy and control group. Study including healthy neonates, prophylaxis effect, non-RCT, and non-English studies were excluded in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine out of 14 RCT studies showed significant reduction of total serum bilirubin levels with various duration after receiving probiotic supplementation during phototherapy. Some of RCT studies reported significant changes in indirect bilirubin levels, duration of phototherapy, duration of hospital stay. Moreover, there were four studies that found no significant changes on total serum bilirubin levels. No adverse effects or complications are found among those studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Probiotics supplementation in neonatal jaundice therapy was promising beneficial outcome for neonatal jaundice. Further research is required to confirm the consistency of therapeutic effects and adverse reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251350382","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T11:36:08Z","timestamp":1750419368000},"page":"3-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of probiotics supplementation in neonatal jaundice therapy: A systematic review"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1852-115X","authenticated-orcid":false,"given":"Lisa Amelia","family":"Wijaya","sequence":"first","affiliation":[{"name":"Universitas Udayana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putu Wila","family":"Widiastuti","sequence":"additional","affiliation":[{"name":"Universitas Warmadewa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni Nyoman Metriani","family":"Nesa","sequence":"additional","affiliation":[{"name":"Medical Faculty of Universitas Udayana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Gusti Ngurah Sanjaya","family":"Putra","sequence":"additional","affiliation":[{"name":"Medical Faculty of Universitas Udayana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24838"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058859"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2017-0234"},{"key":"e_1_3_3_5_2","volume-title":"Jaundice in newborn babies under 28 days (CG98)","author":"NICE","year":"2023","unstructured":"NICE. 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The effect of probiotics on reducing hospitalization duration in infants with hyperbilirubinemia. Iran J Pediatr 2017; 27(1): 1\u20135.","journal-title":"Iran J Pediatr"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.14238\/pi63.4.2023.219-25"},{"issue":"46","key":"e_1_3_3_15_2","first-page":"617","article-title":"Impact of probiotics on neonatal hyperbilirubinemia","volume":"22","author":"Kamel TR","year":"2019","unstructured":"Kamel TR, Afia AAE, Hablas HR, et al. Impact of probiotics on neonatal hyperbilirubinemia. Al-Azhar Journal of Ped 2019; 22(46): 617\u2013628.","journal-title":"Al-Azhar Journal of Ped"},{"issue":"2","key":"e_1_3_3_16_2","first-page":"384","article-title":"Effect of probiotic \u201cL.reuteri\u201d association on the reduction of serum bilirubin in neonatal jaundice","volume":"14","author":"Makhoul G","year":"2018","unstructured":"Makhoul G, Mardini J, Ojaimi MA, et al. Effect of probiotic \u201cL.reuteri\u201d association on the reduction of serum bilirubin in neonatal jaundice. Eur Sci J 2018; 14(2): 384\u2013391.","journal-title":"Eur Sci J"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2022.10.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.30659\/sainsmed.v14i2.34029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.34172\/ipp.2022.02"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.59670\/ml.v20i7.5809"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.48036\/apims.v17i2.494"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.315.7921"},{"issue":"10","key":"e_1_3_3_23_2","first-page":"5925","article-title":"Effect of probiotics on serum bilirubin level in term neonates with jaundice: a randomized clinical trial","volume":"5","author":"Zahed PY","year":"2017","unstructured":"Zahed PY, Ahmadpour-kacho M, Ahmadi Jazi A, et al. 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