{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:11:57Z","timestamp":1784560317523,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter closure of patent ductus arteriosus (PDA) in small, premature infants is increasingly performed in the contemporary practice. Data regarding optimal timing of PDA closure are scarce. We therefore decided to compare morbidity and mortality of early and late device closure in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hospitalizations of 166,583 newborn infants diagnosed with PDA were identified from the Kids\u2019 Inpatient Database (KID) in 2009, 2012, 2016, and 2019. Of these, 299 preterm infants (gestational age (GA) \u226432\u00a0weeks, birth weight &lt;1500\u00a0grams) underwent percutaneous PDA closure. Characteristics and periprocedural outcomes were compared between early (\u226430\u00a0days) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 120) and late PDA closure (&gt;30\u00a0days) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 179).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age (\u00b1standard deviation) for early PDA closure was 18.6\u00a0days \u00b1 7 and 67.3\u00a0days \u00b1 36.5 in late PDA closure. Comorbidities including respiratory distress syndrome\/bronchopulmonary dysplasia, heart failure, and pulmonary hypertension were comparable between the two groups. There was no difference in mortality or referral for surgical ligation between early and late closure. Postprocedural vascular complications were low, but higher in patients with early PDA closure (3.3% vs 0%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.025). While the total length of hospital stay was longer in late PDA closure group (121.1\u00a0days \u00b1 51.7 vs 81.5\u00a0days \u00b1 48.8;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = &lt;0.01), postprocedural length of stay was paradoxically longer in the early closure group (69\u00a0days \u00b1 43.6 vs 57.5\u00a0days \u00b1 43,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was no statistical difference in in-hospital mortality; however, there is a trend toward higher mortality in the early closure group. Major periprocedural complications are comparable between early and late PDA closure, except vascular complications that were higher with early PDA closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251350986","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T07:31:08Z","timestamp":1750059068000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants"],"prefix":"10.1177","volume":"19","author":[{"given":"Mohamed F","family":"Elsisy","sequence":"first","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-4070","authenticated-orcid":false,"given":"George T","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-6794","authenticated-orcid":false,"given":"Elizabeth H","family":"Stephens","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-4464","authenticated-orcid":false,"given":"Gayathri","family":"Sreenivasan","sequence":"additional","affiliation":[{"name":"Westchester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Children\u2019s National Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"issue":"4","key":"e_1_3_3_2_2","first-page":"100968","article-title":"A global perspective on PDA management in the extremely premature: shifting trend toward transcatheter closure","volume":"2","author":"Sathanandam S","year":"2023","unstructured":"Sathanandam S, McNamara P, Pedra C, et al. A global perspective on PDA management in the extremely premature: shifting trend toward transcatheter closure. J Soc Cardiovasc Angiogr Interv 2023; 2(4): 100968.","journal-title":"J Soc Cardiovasc Angiogr Interv"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.09.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00772-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.07.025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.04.014"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1209"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025784"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0347-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0006-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.01.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.046"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28973"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-023-01552-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-312582"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-023-01741-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102356"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000915"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002923"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-4258"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.09.012"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.10.035"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2927"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019356"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.03.141"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02665-3"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12196"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1768-5"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27091"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.10.020"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28502"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.03.040"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.09.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2781"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.124"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.2"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251350986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251350986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251350986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:27:05Z","timestamp":1777588025000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251350986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/19345798251350986"],"URL":"https:\/\/doi.org\/10.1177\/19345798251350986","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]}}}