{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:29Z","timestamp":1777876589820,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"\n Background<\/jats:title>\n Chorioamnionitis is a significant perinatal infection that adversely affects maternal and neonatal outcomes. Diagnostic criteria, including Lencki\u2019s criteria, are frequently used; however, they include subjective indicators, limiting their clinical utility. We aimed to establish diagnostic criteria using only objective indicators.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study involved patients who delivered at our hospital and underwent placental pathological examination from 2003 to 2022. Based on the Blanc classification, patients were classified into the CAM II\/III (stage 2 or 3) and CAM I (stage 1) groups, followed by between-group comparisons of maternal and neonatal outcomes. Diagnostic indicators were selected through multivariate logistic regression analysis and used to develop a diagnostic model. Receiver operating characteristic curves were generated to compare the diagnostic performances of the new and previous criteria.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 862 included patients, 538 and 324 were classified as CAM II\/III and CAM I, respectively. The CAM II\/III group showed significantly higher rates of neonatal acidosis and maternal postpartum hospitalization \u226510\u00a0days. In the new model, scores were assigned as follows: body temperature \u226538.5\u00b0C (2 points), C-reactive protein \u22651.0\u00a0mg\/dL (2 points), white blood cell count \u226512 \u00d7 10\n 9<\/jats:sup>\n \/L (1 point), and nulliparity (1 point). A total score \u22654 points was considered the diagnostic threshold. The new criteria outperformed the existing criteria, with an area under the curve (AUC) value of 0.741 compared to 0.621 (\n p<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The new criteria showed improved diagnostic accuracy for chorioamnionitis, which may facilitate early diagnosis and timely intervention for improved perinatal outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/19345798251351002","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:05:19Z","timestamp":1750205119000},"page":"553-559","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["New diagnostic criteria for clinical chorioamnionitis using only objective indicators: A retrospective study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2834-0819","authenticated-orcid":false,"given":"M","family":"Sumino","sequence":"first","affiliation":[{"name":"Department of Integrated Women\u2019s Health, St. Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Integrated Women\u2019s Health, St. Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-6208","authenticated-orcid":false,"given":"T","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Integrated Women\u2019s Health, St. Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Integrated Women\u2019s Health, St. Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002984"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.02.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.09.017"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00649"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0322-0"},{"key":"e_1_3_4_7_2","first-page":"CD010976","article-title":"Antibiotic regimens for management of intra-amniotic infection","volume":"12","author":"Chapman E","year":"2014","unstructured":"Chapman E, Reveiz L, Illanes E, et al. Antibiotic regimens for management of intra-amniotic infection. Cochrane Database Syst Rev 2014; 12: CD010976.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(13)90462-2"},{"key":"e_1_3_4_9_2","first-page":"67","article-title":"Pathology of the placenta, membranes, and umbilical cord in bacterial, fungal, and viral infections in man","volume":"22","author":"Blanc WA","year":"1981","unstructured":"Blanc WA. Pathology of the placenta, membranes, and umbilical cord in bacterial, fungal, and viral infections in man. Monogr Pathol 1981; 22: 67\u2013132.","journal-title":"Monogr Pathol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.654596"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.05.010"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1711725"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001246"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e90046"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.003"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(21)00165-0"},{"issue":"6","key":"e_1_3_4_17_2","first-page":"909","article-title":"Chorioamnionitis and uterine function","volume":"95","author":"Mark SP","year":"2000","unstructured":"Mark SP, Croughan-Minihane MS, Kilpatrick SJ. Chorioamnionitis and uterine function. Obstet Gynecol 2000; 95(6 Pt 1): 909\u2013912.","journal-title":"Obstet Gynecol"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251351002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251351002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251351002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:27:07Z","timestamp":1777588027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251351002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/19345798251351002"],"URL":"https:\/\/doi.org\/10.1177\/19345798251351002","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]}}}