{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:25Z","timestamp":1777876585385,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glycemic variability is a common complication affecting very preterm infants. Hypoglycemia and hyperglycemia have been associated with increased neonatal morbidities, including retinopathy of prematurity (ROP). However, it remains unclear whether glycemic variability contributes to a higher risk of ROP. Our study investigated the relationship between glycemic variability and severe, treatment-requiring ROP in preterm infants during the first 28\u00a0days of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective case-control study was conducted on infants with a birthweight \u22641500\u00a0g and\/or gestational age \u226430\u00a0weeks. Cases included infants with severe ROP requiring treatment (\n                      <jats:italic>n<\/jats:italic>\n                      = 31) and were matched to controls with no ROP or ROP not requiring treatment (\n                      <jats:italic>n<\/jats:italic>\n                      = 62) in a 1:2 ratio. Glycemic variability was quantified as the standard deviation of mean glucose levels. Statistical analysis included t-tests, chi-squared, and Fisher\u2019s tests, with logistic regression models to adjust for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographics and clinical variables were similar in cases and controls except for ethnicity and PDA. The mean glucose concentration was 130.74\u00a0mg\/dl (\u00b139.98) in the treatment group and 121.26\u00a0mg\/dl (\u00b147.44) in controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.32). The number of hypo and hyperglycemic episodes was not significantly different between the two groups. Glycemic variability was also similar in cases and controls (mean SD = 36.01 vs 33.45, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.31). After adjusting for confounders, no association was found between glycemic variability and ROP treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study did not identify a significant association between glycemic variability and the development of severe, treatment-requiring ROP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251359897","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T11:16:08Z","timestamp":1752318968000},"page":"589-596","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of glycemic variability in the development of treatment-requiring retinopathy of prematurity"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0337-0336","authenticated-orcid":false,"given":"Radhika","family":"Maddali","sequence":"first","affiliation":[{"name":"Division of Neonatology, Albert Einstein College of Medicine, The Children\u2019s Hospital at Montefiore, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3569-0250","authenticated-orcid":false,"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Mian","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Children\u2019s Hospital at Montefiore, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-7124","authenticated-orcid":false,"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-6305","authenticated-orcid":false,"given":"T.","family":"Havranek","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Renaissance School of Medicine, Stony Brook University, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1413"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0732-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3061"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208129"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003477"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002949"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2386ED"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)80282-0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052456"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058813"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2025-071425"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/neo.21-4-e249"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911781"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2584"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1309"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053924"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-009-9201-x"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.9.1497"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650617"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.17.9.875.5134"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0628"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0449"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04140-w"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301661"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-7-29"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep09091"},{"issue":"7","key":"e_1_3_4_35_2","first-page":"4188","article-title":"Maternal sociodemographic risk factors for retinopathy of prematurity","volume":"63","author":"Strawbridge JC","year":"2022","unstructured":"Strawbridge JC, Janzen C, Chu A, et al. 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