{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:28Z","timestamp":1777876588053,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Preterm neonates with respiratory distress often require advanced ventilation strategies to prevent respiratory failure. High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) can be utilized as a lung-protective modality that reduces ventilation induced lung injury. However, its effect on cerebral hemodynamics remains unclear. Our study aimed to compare the impacts of HFOV-VG versus HFOV alone on cerebral blood flow velocity among preterm neonates with respiratory failure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this pilot randomized controlled trial, 60 premature newborns (gestational age of 35 weeks or less) with respiratory distress who failed on conventional mechanical ventilation (CMV) were randomized to receive either HFOV or HFOV-VG as rescue respiratory therapy. Doppler cerebral blood flow velocity measurements, intraventricular hemorrhage (IVH) incidence, carbon dioxide (CO\n 2<\/jats:sub>\n ) levels, and oxygen requirements were assessed at baseline, after 24 hours, and after 3\u00a0days of ventilation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were no significant differences in cerebral blood flow velocity measurements or IVH incidence between the two groups across all time points (\n p<\/jats:italic>\n > 0.05). However, HFOV-VG demonstrated lower fluctuations in tidal volume, fewer out-of-target CO\n 2<\/jats:sub>\n episodes, and reduced oxygen requirements compared to HFOV alone.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n HFOV-VG and HFOV alone showed comparable effects on cerebral blood flow and IVH incidence in premature neonates. HFOV-VG may offer additional advantages in maintaining stable ventilation parameters and minimizing CO\n 2<\/jats:sub>\n fluctuations, potentially reducing the risk of lung injury.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/19345798251363451","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:43:06Z","timestamp":1754397786000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of volume guarantee-high frequency oscillatory ventilation on cerebral blood flow in preterm neonates"],"prefix":"10.1177","volume":"19","author":[{"given":"Nehal Mohamed","family":"El-Raggal","sequence":"first","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha Mohamed","family":"Khafagy","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivan Taha","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9571-9721","authenticated-orcid":false,"given":"Mohamed Abdullah","family":"Moussa","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3294-8285","authenticated-orcid":false,"given":"Arwa Hamdy","family":"Al sharabasy","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"1","article-title":"Respiratory distress in neonatal intensive care unit in Benha University Hospital","volume":"41","author":"Afifi WE","year":"2024","unstructured":"Afifi WE, Shaheen AM, Khattab TM, et al. Respiratory distress in neonatal intensive care unit in Benha University Hospital. BMFJ 2024; 41: 1\u20137.","journal-title":"BMFJ"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.813478"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.29390\/cjrt-2019-004"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23759"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2018.07.003"},{"issue":"2","key":"e_1_3_5_7_2","first-page":"9","article-title":"Hemodynamic effects of high-frequency oscillatory ventilation with volume guarantee in a piglet model of respiratory distress syndrome","volume":"16","author":"Bhogal J","year":"2021","unstructured":"Bhogal J, Solev\u00e5g AL, O\u2019Reilly M, et al. Hemodynamic effects of high-frequency oscillatory ventilation with volume guarantee in a piglet model of respiratory distress syndrome. Neonatology 2021; 16(2): 9\u201317.","journal-title":"Neonatology"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x2022e11543"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-42876-7.00024-7"},{"key":"e_1_3_5_10_2","first-page":"213","volume-title":"V\u00e9locim\u00e9trie ultrasonore Doppler, Peronneau","author":"Pourcelot L","year":"1975","unstructured":"Pourcelot L. Applications cliniques de l\u2019examen Doppler transcutan\u00e9. In: V\u00e9locim\u00e9trie ultrasonore Doppler, Peronneau, 1975, pp. 213\u2013240."},{"key":"e_1_3_5_11_2","first-page":"266","volume-title":"Cardiovascular applications of ultrasound","author":"G\u00f6sling RG","year":"1974","unstructured":"G\u00f6sling RG, King DH. Continuous wave ultrasound as an alternative and complement to X-ray in vascular examinations. In: Reneman RE (ed). 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