{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:53:53Z","timestamp":1783756433395,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The rehydration approach for hypernatremic dehydration in newborns is challenging. A new treatment protocol was introduced in the NICU for moderate hypernatremic dehydrated (MHD) newborns to achieve safer and more effective serum sodium (Na+) correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study in a four-level NICU examined term and near term MHD (150\u2013169 mEq\/L) newborns. In a novel hypernatremic dehydration treatment protocol, 49 newly diagnosed MHD patients were in group 1, while 54 previously treated control MHD patients were in group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      49 neonates received the novel treatment protocol (group 1), and data from 54 neonates were obtained from hospital records (group 2). Serum Na+ correction rate was significantly lower in group 1 compared to group 2, with a median serum Na+ level of 0.66 versus 1.05 mEq\/L\/h,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001. The proportion of patients who were treated with pure oral rehydration was significantly higher in group 1 compared to group 2 (67.3% vs 25.9%,\n                      <jats:italic toggle=\"yes\">p&lt;0.001<\/jats:italic>\n                      ). Multiple regression analysis was performed to determine factors associated with use of intravenous rehydration: initial serum Na+ [odds ratio (OR):1.515, 95% confidence interval (CI) 1.17\u20131.94,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001] and serum uric acid [OR: 1.495, 95% CI 1.092\u20132.00,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.012] in model 2; belonging to Group 2 [OR: 28.267, 95% CI 10.321\u201353.69,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001]; each additional delay in the day of postnatal admission [OR: 1.381, 95% CI 1.011\u20131.888,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.043]; and initial serum Na+ [OR: 1.574, 95% CI 1.216\u20132.037,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001] in model 4 were significantly associated with intravenous rehydration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral rehydration therapy offers slower sodium reduction and has a low treatment failure rate in MHD newborns. It can be the primary treatment approach, while intravenous therapy should be considered based on the patient\u2019s overall clinical and biochemical status, not just initial sodium levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251363457","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T14:29:46Z","timestamp":1754576986000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Newborn hypernatremic dehydration: A prospective study reducing the usage of intravenous liquids in moderate cases"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-7877","authenticated-orcid":false,"given":"Deniz","family":"Yaprak","sequence":"first","affiliation":[{"name":"G\u00fclhane Training and Research Hospital, Division of Neonatology, Department of Pediatrics, University of Health Sciences, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belma Sayg\u0131l\u0131","family":"Karag\u00f6l","sequence":"additional","affiliation":[{"name":"University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02313.x"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182983bac"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701398256"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.104331"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2018.06.005"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001794"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-024-05044-x"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2005.07.019"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2016.0054"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000454980"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","unstructured":"Y\u0131ld\u0131zda\u015f HY Demirel N \u0130nce Z. Turkish Neonatal Society Guideline on fluid and electrolyte balance in the newborn. Turk Pediatri Ars. 2018;5325(Suppl 1):S55-S64. Published 2018 Dec 25. DOI:10.5152\/TurkPediatriArs.2018.01807.","DOI":"10.5152\/TurkPediatriArs.2018.01807"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20190424-01"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.4.f349"},{"issue":"2","key":"e_1_3_7_15_2","first-page":"95","article-title":"Hypernatremic dehydration in young children: is there a solution?","volume":"18","author":"Ben-Shalom E","year":"2016","unstructured":"Ben-Shalom E, Toker O, Schwartz S. Hypernatremic dehydration in young children: is there a solution? Isr Med Assoc J 2016; 18(2): 95\u201399.","journal-title":"Isr Med Assoc J"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.18233\/APM40No2pp99-1061782"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.819334"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-19921001-04"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2299568"},{"issue":"6","key":"e_1_3_7_20_2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.32641\/rchped.v91i6.1399","article-title":"Caracterizaci\u00f3n de reci\u00e9n nacidos a t\u00e9rmino con deshidrataci\u00f3n hipernatr\u00e9mica [Characterization of full term newborns with hypernatremic dehydration]","volume":"91","author":"Del Castillo CG","year":"2020","unstructured":"Del Castillo CG, Suares AD, Granja AM, et al. Caracterizaci\u00f3n de reci\u00e9n nacidos a t\u00e9rmino con deshidrataci\u00f3n hipernatr\u00e9mica [Characterization of full term newborns with hypernatremic dehydration]. Rev Chil Pediatr 2020; 91(6): 874\u2013880.","journal-title":"Rev Chil Pediatr"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2021.20153"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251363457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251363457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251363457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:27:12Z","timestamp":1777588032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251363457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/19345798251363457"],"URL":"https:\/\/doi.org\/10.1177\/19345798251363457","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}