{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:50:02Z","timestamp":1782708602302,"version":"3.54.5"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm neonates. Identifying early markers of impaired intestinal perfusion may aid detecting an association with the development of NEC. This study aims to evaluate the role of Doppler ultrasound of the superior mesenteric artery (SMA) and celiac artery (CA) and its association with NEC in preterm neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective, single-center case\u2013control study. Eligible infants were born at &lt;29\u00a0weeks\u2019 gestation; we excluded those with chromosomal abnormalities, major anomalies, and those without Doppler assessments. NEC cases (Bell stage \u2265II) were matched to controls on gestational age and birth weight. We compared SMA and CA Doppler parameters\u2014peak systolic velocity (PSV), end-diastolic velocity (EDV) of NEC and control infants obtained at the end of the first and between 2\n                      <jats:sup>nd<\/jats:sup>\n                      and 3\n                      <jats:sup>rd<\/jats:sup>\n                      weeks of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 44 preterm infants (NEC = 21; controls = 23), Doppler assessment in the 1\n                      <jats:sup>st<\/jats:sup>\n                      week showed lower\n                      <jats:bold>CA<\/jats:bold>\n                      PSV in NEC versus controls (AMD = \u221227.7\u00a0cm\/s [\u221253.58, \u22121.81];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0371) after adjustment for PDA, birth weight, and gestational age. In weeks 2\u20133, and before NEC onset, NEC infants had lower\n                      <jats:bold>SMA<\/jats:bold>\n                      PSV (AMD = \u221235.7\u00a0cm\/s [\u221268.5, \u22123.00];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.036) in models adjusted for PDA. No significant differences were found in CA parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced CA PSV during the first week of life, and reduced SMA PSV prior to NEC onset reflects impaired splanchnic perfusion preceding NEC and may be useful to clinicians in stratifying neonates at a risk of developing NEC in advance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251377439","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:09:32Z","timestamp":1757761772000},"page":"172-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between celiac and superior mesenteric arteries\u2019 Doppler flow parameters and risk of necrotizing enterocolitis in preterm infants"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-4575","authenticated-orcid":false,"given":"Raef","family":"Qeretli","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario (CHEO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4439-1214","authenticated-orcid":false,"given":"Abdalkarim","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Queen\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-2499","authenticated-orcid":false,"given":"Nadya","family":"Ben Fadel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario (CHEO)"},{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112960"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30341-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.02.013"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"issue":"1","key":"e_1_3_4_6_2","first-page":"179","article-title":"Necrotizing enterocolitis: treatment based on staging criteria","volume":"33","author":"Walsh MC","year":"1986","unstructured":"Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin 1986; 33(1): 179\u2013201.","journal-title":"Pediatr Clin"},{"key":"e_1_3_4_7_2","volume-title":"Anatomy, abdomen and pelvis: celiac trunk","author":"Ahluwalia N","year":"2025","unstructured":"Ahluwalia N, Nassereddin A, Arbor TC, et al. Anatomy, abdomen and pelvis: celiac trunk. StatPearls Publishing, 2025."},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.531316"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1285-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0272"},{"issue":"1","key":"e_1_3_4_11_2","first-page":"13","article-title":"Abnormal gut blood flow velocities in neonates at risk of necrotising enterocolitis","volume":"15","author":"Coombs RC","year":"1992","unstructured":"Coombs RC, Morgan M, Durbin GM, et al. Abnormal gut blood flow velocities in neonates at risk of necrotising enterocolitis. J Pediatr Gastroenterol Nutr 1992; 15(1): 13\u201319.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-016-0228-z"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.7_Spec_No.793"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2002.00445.x"},{"issue":"1","key":"e_1_3_4_15_2","first-page":"4126245","article-title":"Necrotizing enterocolitis in moderate preterm infants","volume":"2018","author":"Nair J","year":"2018","unstructured":"Nair J, Longendyke R, Lakshminrusimha S. Necrotizing enterocolitis in moderate preterm infants. BioMed Res Int 2018; 2018(1): 4126245.","journal-title":"BioMed Res Int"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-92"},{"issue":"1","key":"e_1_3_4_17_2","article-title":"Evaluation of superior mesenteric artery (SMA) and celiac artery (CA) blood flow pattern in preterm infants and factors influencing the blood flow","volume":"5","author":"Unde NR","year":"2019","unstructured":"Unde NR, El-Atawi KM, Elhalik MS, et al. Evaluation of superior mesenteric artery (SMA) and celiac artery (CA) blood flow pattern in preterm infants and factors influencing the blood flow. Neonatal and Pediatric Medicine 2019; 5(1).","journal-title":"Neonatal and Pediatric Medicine"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2022"},{"key":"e_1_3_4_19_2","article-title":"A language and environment for statistical computing","author":"R Core Team R","year":"2024","unstructured":"R Core Team R. 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