{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:32Z","timestamp":1777876592269,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are variations in practices regarding the initiation and stopping of caffeine for apnea of prematurity among neonates above 28\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the proportion of recurrence of apnea of prematurity among neonates between 28 and 32\u00a0weeks on stopping caffeine after an apnea-free period of 7\u00a0days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This was a prospective, observational study conducted in a tertiary care government medical college from April 2023 to May 2024. Study population were neonates between 28 and 32\u00a0weeks gestation. Injection Caffeine citrate was started for all within 2\u00a0hours of birth and it was stopped after an apnea-free period of 7\u00a0days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of the total 300 neonates enrolled, 285 were available for primary outcome analysis. Out of the 38.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 109) who developed recurrence of apnea, only 11.9% (CI: 8.4%\u201316.3%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 34) was due to apnea of prematurity. Late-onset sepsis was the major cause in the rest. The median day of recurrence was 7\u00a0days (IQR 3) after stopping caffeine. On multivariable logistic regression birth weight less than 1250\u00a0g was the only significant predictor for the recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of recurrence of apnea of prematurity was only 11.9 % (CI 8.4%\u201316.3%) among 28\u201332 weeks babies on early stopping of caffeine. For judicious use of caffeine, considering its cost and side effects, it may be reasonable to stop it after an apnea-free period of 7\u00a0days. Close monitoring is required for 7\u201310 days in babies less than 1250\u00a0g.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251380137","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:17:32Z","timestamp":1758673052000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrence of apnea of prematurity following early discontinuation of caffeine: A prospective analytical study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7319-4450","authenticated-orcid":false,"given":"Nikhil","family":"Kumar","sequence":"first","affiliation":[{"name":"Government Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-8169","authenticated-orcid":false,"given":"Aswathy","family":"Rahul","sequence":"additional","affiliation":[{"name":"Government Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-5736","authenticated-orcid":false,"given":"Anand","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Government Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Sujatha","sequence":"additional","affiliation":[{"name":"Government Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobhakumar Saraswathy","family":"Amma","sequence":"additional","affiliation":[{"name":"Government Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_3_8_2_2","first-page":"437","volume-title":"Cloherty and Stark\u2019s Manual of Neonatal Care. South Asian","author":"Stark AR","year":"2021","unstructured":"Stark AR. Apnea. In: Eichenwald EC, Hansen AR, Martin CR, et al. (eds). Cloherty and Stark\u2019s Manual of Neonatal Care. South Asian. Wolters Kluwer, 2021, p. 437."},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.09.017"},{"key":"e_1_3_8_4_2","first-page":"438","volume-title":"Cloherty and Stark\u2019s Manual of Neonatal Care. South Asian","author":"Stark AR","year":"2021","unstructured":"Stark AR. Apnea. In: Eichenwald EC, Hansen AR, Martin CR, et al. (eds). Cloherty and Stark\u2019s Manual of Neonatal Care. South Asian. 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