{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:23:06Z","timestamp":1777944186359,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bullous drug eruptions are rare but serious adverse reactions in neonates. Cefotaxime, a commonly used third-generation cephalosporin in neonatal intensive care, can rarely cause severe cutaneous adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We report a case of a term, large-for-gestational-age male neonate who developed bullous drug eruption following intravenous cefotaxime administration on Day 3 of life. The patient was initially admitted for decreased urine output and received prophylactic cefotaxime for suspected sepsis. Immediately after the fifth dose of intravenous cefotaxime, blister formation occurred over all five left toes distal to the IV cannula site. This progressed to gangrenous changes involving all five toes with erythematous discoloration extending to the metacarpophalangeal joints. Conservative management, including antibiotics and local wound care, resulted in gradual improvement, characterized by the formation of demarcation lines and the resolution of inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights a rare but serious complication of cefotaxime use in neonates. Healthcare providers should be aware of this potential severe cutaneous adverse reaction, particularly when cefotaxime is administered via peripheral intravenous access. Early recognition and immediate discontinuation of the offending drug, along with conservative management, can lead to favorable outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251384933","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:24:31Z","timestamp":1759278271000},"page":"329-333","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized bullous drug reaction to cefotaxime leading to wet gangrene in a neonate: A case report"],"prefix":"10.1177","volume":"19","author":[{"given":"K Krishna","family":"Kumar","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-110X","authenticated-orcid":false,"given":"Choudri Muzafar","family":"Paswal","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-4203","authenticated-orcid":false,"given":"Swasthi Kabi","family":"Satpathy","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7012-0283","authenticated-orcid":false,"given":"Gudipudi Sai Vamsi","family":"Manoj","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-5219","authenticated-orcid":false,"given":"Neeraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.10.006"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.100403"},{"issue":"3","key":"e_1_3_5_4_2","first-page":"177","article-title":"Cefotaxime-induced near-fatal anaphylaxis in a neonate: a case report and review of literature","volume":"15","author":"Chopra A","year":"2011","unstructured":"Chopra A, Sharma R, Rao GS. Cefotaxime-induced near-fatal anaphylaxis in a neonate: a case report and review of literature. Indian J Crit Care Med 2011; 15(3): 177\u2013179.","journal-title":"Indian J Crit Care Med"},{"issue":"3","key":"e_1_3_5_5_2","first-page":"367","article-title":"Cefotaxime versus ampicillin as empirical monotherapy in neonates with risk factors for early onset sepsis","volume":"177","author":"Gundersen KO","year":"2018","unstructured":"Gundersen KO, Henriksen TB. Cefotaxime versus ampicillin as empirical monotherapy in neonates with risk factors for early onset sepsis. Eur J Pediatr 2018; 177(3): 367\u2013374.","journal-title":"Eur J Pediatr"},{"issue":"4","key":"e_1_3_5_6_2","first-page":"143","article-title":"Antibiotic agents - an overview with special reference to the skin","volume":"17","author":"Zhai H","year":"2004","unstructured":"Zhai H, Maibach HI. Antibiotic agents - an overview with special reference to the skin. Skin Pharmacology 2004; 17(4): 143\u2013152.","journal-title":"Skin Pharmacology"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(77)90398-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.45.3.469"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002380000194"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251384933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251384933","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251384933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:49:27Z","timestamp":1777708167000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251384933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/19345798251384933"],"URL":"https:\/\/doi.org\/10.1177\/19345798251384933","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}