{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:23:37Z","timestamp":1777944217094,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the relationship between placental oxygen transport on MRI and fetal birth weight, and to identify associated transcriptional pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study of six monochorionic twin pairs. For each pair, the twin with the higher placental oxygen time-to-plateau (TTP) was designated as Group A and the co-twin with the lower TTP as Group B. RNA sequencing of cord blood was performed to assess differential gene expression. Analyses were performed using paired methods to account for within-pair comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On descriptive analysis, higher TTP twins (Group A) had lower mean birth weight than their lower TTP co-twins (Group B) (2121 \u00b1 256\u00a0g vs 2397 \u00b1 283\u00a0g), but this difference was not statistically significant on paired analysis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.51). TTP values were also not significantly different within pairs (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.17). Across all twins, higher TTP was associated with lower birth weight (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02). No differentially expressed genes or pathways were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort of monochorionic twin pairs, the twin with slower placental oxygen transport tended to have lower birth compared with its co-twin, although this difference was not statistically significant on paired analysis. Higher TTP was correlated with lower birth weight across twins, but no transcriptomic differences were identified. Larger paired datasets are needed to further explore these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251387335","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:22:48Z","timestamp":1760520168000},"page":"307-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between placental oxygen transport, fetal birth weight, and umbilical cord transcriptome in monochorionic twins"],"prefix":"10.1177","volume":"19","author":[{"given":"S. S.","family":"Ali","sequence":"first","affiliation":[{"name":"University of Miami Miller School of Medicine and Holtz Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine and Holtz Children\u2019s Hospital"},{"name":"Boston Children\u2019s Hospital, Harvard Medical School, Division of Genetics and Genomics"},{"name":"The Manton Center for Orphan Disease Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Turk","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-8970","authenticated-orcid":false,"given":"K.","family":"Im","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-4505","authenticated-orcid":false,"given":"C.","family":"Bibbo","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-8861","authenticated-orcid":false,"given":"K.","family":"Schmitz-Abe","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine and Holtz Children\u2019s Hospital"},{"name":"Boston Children\u2019s Hospital, Harvard Medical School, Division of Genetics and Genomics"},{"name":"The Manton Center for Orphan Disease Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6736-7601","authenticated-orcid":false,"given":"M.","family":"Ramesh","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine and Holtz Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. E.","family":"Grant","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. B.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine and Holtz Children\u2019s Hospital"},{"name":"Boston Children\u2019s Hospital, Harvard Medical School, Division of Genetics and Genomics"},{"name":"The Manton Center for Orphan Disease Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.021"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/neo.19-8-e456"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.03.004"},{"key":"e_1_3_4_5_2","volume-title":"Placental insufficiency","author":"Wardinger JE","year":"2025","unstructured":"Wardinger JE, Ambati S. Placental insufficiency. StatPearls, 2025."},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.03.008"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13358"},{"issue":"5","key":"e_1_3_4_8_2","first-page":"320","article-title":"Functional magnetic resonance imaging: the basics of blood-oxygen-level dependent (BOLD) imaging","volume":"49","author":"Forster BB","year":"1998","unstructured":"Forster BB, MacKay AL, Whittall KP, et al. Functional magnetic resonance imaging: the basics of blood-oxygen-level dependent (BOLD) imaging. Can Assoc Radiol J 1998; 49(5): 320\u2013329.","journal-title":"Can Assoc Radiol J"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03450-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad383"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.04.008"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000221"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251387335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798251387335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798251387335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:49:14Z","timestamp":1777708154000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798251387335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/19345798251387335"],"URL":"https:\/\/doi.org\/10.1177\/19345798251387335","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}