{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:36:36Z","timestamp":1777876596969,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Carbapenem-resistant\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      (CRKP) presents a significant challenge for infection control and treatment in the neonatal population. The aim of the study is to identify risk factors associated with mortality of in neonates infected with CRKP in the NICU.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective review of medical records from January to December 2018, including all neonates with positive\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      blood cultures. Possible risk factors such as birth weight, gestational age, length of stay, episodes of sepsis, use of mechanical ventilation, parenteral nutrition, central access, blood transfusion, laboratory values, and prior antibiotics use before isolation were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 402 neonates clinically diagnosed with sepsis, 50 had positive\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      cultures, with 80% identified as CRKP. Among CRKP cases, mortality was associated with PRC transfusion (100% vs 46.2%; RR 5.5; 95% CI 2.67\u201311.34; p &lt; 0.001), elevated inflammatory markers (CRP: 58.2 vs 27.75\u00a0mg\/dL, p = 0.01; PCT: 21.99 vs 2.63\u00a0ng\/mL, p = 0.03), and prior carbapenem use (77.8% vs 38.5%; RR 5.6; 95% CI 1.33\u201323.62; p = 0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The study highlights that a majority of neonatal sepsis cases caused by\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      in the Indonesian NICU were due to carbapenem-resistant strains (CRKP). CRKP infection was significantly associated with higher mortality, particularly among neonates who had received packed red cell transfusions, showed elevated inflammatory markers, or had prior exposure to carbapenem antibiotics. These findings underscore the urgent need for enhanced infection control measures, judicious antibiotic use, and targeted interventions to reduce mortality from CRKP in neonatal care settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251391014","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:20:37Z","timestamp":1760725237000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncovering the risk factors for mortality of carbapenem-resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    infections in Indonesian NICU: A study from a referral hospital"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-6244","authenticated-orcid":false,"given":"Putri Maharani Tristanita","family":"Marsubrin","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital"},{"name":"Department of Child Health, Universitas Indonesia Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-2005","authenticated-orcid":false,"given":"Muhamad Azharry Rully","family":"Sjahrulla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8907-842X","authenticated-orcid":false,"given":"Jessica Sylvania","family":"Oswari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2594-2942","authenticated-orcid":false,"given":"Valerie","family":"Viola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9569-8167","authenticated-orcid":false,"given":"Kanya Lalitya Jayanimitta","family":"Sugiyarto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.01.026"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2023.12.002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119571"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-80974-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106933"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12341"},{"issue":"3","key":"e_1_3_4_8_2","first-page":"636","article-title":"Karakteristik resistensi Klebsiella pneumoniae yang resisten karbapenem pada beberapa rumah sakit di Indonesia dan pemeriksaan laboratorium","volume":"1","author":"Harapan IK","year":"2018","unstructured":"Harapan IK, Tahulending A, Tumbol MVL. Karakteristik resistensi Klebsiella pneumoniae yang resisten karbapenem pada beberapa rumah sakit di Indonesia dan pemeriksaan laboratorium. Pros Semin Nas Tahun 2018; 1(3): 636\u2013650.","journal-title":"Pros Semin Nas Tahun"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1033305"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.750662"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.09.006"},{"issue":"2","key":"e_1_3_4_12_2","first-page":"112","article-title":"Comparative evaluation of conventional and BACTEC methods for detection of bacterial infection","volume":"15","author":"Alizadeh AM","year":"2016","unstructured":"Alizadeh AM, Kabiri Movahed R, Mohammadnia M. Comparative evaluation of conventional and BACTEC methods for detection of bacterial infection. 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