{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:06:20Z","timestamp":1779789980090,"version":"3.53.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital abnormalities (CAs) are a significant cause of death and disability among children worldwide. Identifying risk factors can help reduce the incidence and mortality associated with CAs. This study aimed to explore the relationship between placental abruption (PA) and congenital abnormalities (CAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted in PubMed (Medline), Web of Science, Scopus, and Science Direct, up to July 10, 2025. The analysis utilized a random-effects model. To evaluate heterogeneity among the studies, we applied the chi-square test (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      ) and the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic. Additionally, regression tests, including Egger\u2019s and Begg\u2019s tests, were carried out to assess publication bias. The quality of observational studies was evaluated using the modified Newcastle\u2013Ottawa Scale (NOS). A p-value of less than 0.05 was considered statistically significant, and the analysis was performed using Stata software, version 13.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, six studies met the inclusion criteria and were included in this systematic review. A significant association was found, with PA increasing the risk of CAs (OR = 2.83; 95% CI: 1.88 to 3.79). Substantial heterogeneity was observed among the studies (I\n                      <jats:sup>2<\/jats:sup>\n                      = 91.9%, P &lt; 0.001). After subgrouping, a significant association between PA and the risk of CAs was observed in both case-control studies (OR = 1.95, 95% CI: 1.51 to 2.38; I\n                      <jats:sup>2<\/jats:sup>\n                      = 0.0%, P = 0.523) and cohort studies (OR = 3.28, 95% CI: 1.68 to 4.88; I\n                      <jats:sup>2<\/jats:sup>\n                      = 95.1%, P &lt; 0.001). Notably, homogeneity was found among the case-control studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates a significant positive association between PA and CAs, but causality cannot be inferred. Thus, it is suggested to monitor for CAs in the fetus of mothers with PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798251398835","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:12:51Z","timestamp":1763442771000},"page":"354-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between placenta abruption and congenital anomalies: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-6432","authenticated-orcid":false,"given":"Amir Mohammad","family":"Salehi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences"},{"name":"Hamadan University of Medical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensiyeh","family":"Jenabi","sequence":"additional","affiliation":[{"name":"Mother and Child Care Research Center, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Kamkari","sequence":"additional","affiliation":[{"name":"Hamadan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07482-7"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.06.059"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-01915-6"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31829a6f91"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04433-z"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-025-02211-8"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb10338.x"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.511346"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309021156"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.1.45.49"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_3_5_16_2","unstructured":"The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality of non-randomized studies in meta-analysis. https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00352.x"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14339"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102873"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.22494"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07612-1"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13091076"},{"key":"e_1_3_5_23_2","volume-title":"Placental abruption and perinatal mortality: abnormal placentation and spontaneous abortion as contributors to left truncation bias","author":"Kinlaw AC","year":"2025","unstructured":"Kinlaw AC, Graham HL, Ananth CV. 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