{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:20:57Z","timestamp":1786116057458,"version":"build-2736575974"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008386","name":"Marmara University Scientific Research Project Coordination Unit","doi-asserted-by":"publisher","award":["SAG-C-TUP-200716-0368"],"award-info":[{"award-number":["SAG-C-TUP-200716-0368"]}],"id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Red blood cell (RBC) transfusion in very preterm infants has been linked to transfusion-related necrotizing enterocolitis (TR-NEC), and peri-transfusion feeding practices vary. We examined whether three different feeding strategies affect cerebral and splanchnic oxygenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single-center randomized pilot trial, infants &lt;32\u00a0weeks\u2019 gestation requiring RBC transfusion were allocated to feeds withheld, feeds reduced by 50%, or feeds continued during transfusion. Near-infrared spectroscopy measured cerebral and splanchnic rSO\n                      <jats:sub>2<\/jats:sub>\n                      from 2\u00a0h before transfusion start through 42\u00a0h after completion (covering the remainder of the 48-h post-initiation window used to define TR-NEC). FTOE and SCOR were calculated. Prespecified primary endpoints were between-group differences in changes in CrSO\n                      <jats:sub>2<\/jats:sub>\n                      , SrSO\n                      <jats:sub>2<\/jats:sub>\n                      , and corresponding FTOE across pre-specified epochs; secondary endpoints were feeding intolerance and TR-NEC (Bell stage \u2265II within 48\u00a0h).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-five infants were enrolled (14, 14, and 17 per group). Splanchnic rSO\n                      <jats:sub>2<\/jats:sub>\n                      increased and splanchnic FTOE decreased during and after transfusion; cerebral rSO\n                      <jats:sub>2<\/jats:sub>\n                      increased after transfusion with decreased cerebral FTOE. No statistically significant differences in, FTOE, or SCOR were detected between feeding groups. TR-NEC occurred in eight infants (2, 1, and 5 per group). In exploratory analyses, infants who developed TR-NEC had lower splanchnic rSO\n                      <jats:sub>2<\/jats:sub>\n                      and higher splanchnic FTOE before and during transfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No statistically significant differences were demonstrated in cerebral or splanchnic oxygenation among three feeding strategies during RBC transfusion. As a pilot, hypothesis-generating study, these findings should not be interpreted as equivalence between strategies and require confirmation in larger trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261431200","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:24:53Z","timestamp":1772493893000},"page":"525-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of feeding strategies during red blood cell transfusion on cerebral and splanchnic oxygenation in preterm infants: Randomized pilot study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-0316","authenticated-orcid":false,"given":"Sevgi","family":"Aslan Tuncay","sequence":"first","affiliation":[{"name":"Marmara University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Marmara University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-3532","authenticated-orcid":false,"given":"Abdullah","family":"Sarioz","sequence":"additional","affiliation":[{"name":"Marmara University Faculty of Medicine"},{"name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-8930","authenticated-orcid":false,"given":"Hulya Selva","family":"Bilgen","sequence":"additional","affiliation":[{"name":"Marmara University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-11002-0005"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2020.02.002"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13036"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.011"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.9643"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64923-7"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1408717"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000872"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.624113"},{"issue":"12","key":"e_1_3_7_11_2","first-page":"1443","article-title":"Near-infrared spectroscopy monitoring and risk of necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis","volume":"11","author":"Gan Y","year":"2024","unstructured":"Gan Y, Li M, Yi W, et al. Near-infrared spectroscopy monitoring and risk of necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis. Children 2024; 11(12): 1443. https:\/\/doi.org\/10.3390\/children11121443","journal-title":"Children"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-025-05731-4"},{"issue":"7","key":"e_1_3_7_13_2","first-page":"1274","article-title":"Near-infrared spectroscopy, packed red blood cell transfusion, and gut injury in preterm infants: a comprehensive review","volume":"65","author":"Vyas M","year":"2025","unstructured":"Vyas M, Milbrandt D, Osgood N, et al. Near-infrared spectroscopy, packed red blood cell transfusion, and gut injury in preterm infants: a comprehensive review. 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