{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:54:09Z","timestamp":1792151649257,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute kidney injury is a frequent but often underrecognized complication in very low birth weight preterm infants. In addition to its established respiratory benefits, caffeine has been suggested to have potential renal-protective effects. The aim of this study was to evaluate the association between early caffeine administration and the incidence of acute kidney injury in preterm infants with a birth weight of 1250g or less.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 156 preterm infants with a gestational age of 30 weeks or less and a birth weight of 1250g or less. Infants were divided into two groups according to caffeine exposure. The caffeine group received prophylactic caffeine within the first 24 h of life, while the control group did not receive caffeine. Acute kidney injury was defined using serum creatinine measurements during the first 14 postnatal days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute kidney injury occurred in 10.3% of infants who received caffeine and in 28.2% of those who did not receive caffeine (p = 0.004). Early caffeine administration was independently associated with a significantly lower risk of acute kidney injury (adjusted odds ratio 0.29; 95% confidence interval 0.11\u20130.74). No infants in the caffeine group developed stage 2 or stage 3 acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early prophylactic caffeine administration is associated with a reduced incidence of acute kidney injury in very low birth weight preterm infants. These findings suggest a potential renal-protective role of caffeine in this vulnerable population. Prospective multicenter studies are needed to confirm these results and evaluate long-term safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261431244","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:53:09Z","timestamp":1773237189000},"page":"597-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond apnea: Early caffeine therapy and the risk of acute kidney injury in very low birth weight infants"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-8912","authenticated-orcid":false,"given":"Gulay","family":"Sonmez Demir","sequence":"first","affiliation":[{"name":"Pamukkale University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Turgut","sequence":"additional","affiliation":[{"name":"Pamukkale University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucel","family":"Pekal","sequence":"additional","affiliation":[{"name":"Pamukkale University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0025-7397","authenticated-orcid":false,"given":"Ece","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Pamukkale University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozmert M. 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