{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:08:22Z","timestamp":1779109702200,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between admission blood gas parameters, particularly pH and base excess (BE), and serial amplitude-integrated electroencephalography (aEEG) background patterns, and to determine whether these early metabolic markers are associated with MRI-defined brain injury severity in neonates with hypoxic\u2013ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 80 neonates (gestational age \u226535 weeks) with moderate-to-severe HIE treated with TH. Admission pH and BE values were recorded. Serial aEEG monitoring was performed at 6, 24, 48, and 72 h of life, and background patterns were classified according to Hellstr\u00f6m-Westas criteria. aEEG recordings were independently interpreted by two reviewers blinded to the clinical and MRI data. Brain MRI was performed in 74 neonates at a median postnatal age of 5 days and was evaluated by a blinded pediatric neuroradiologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Admission BE was significantly associated with aEEG background patterns at all evaluated time points (6 h: p = 0.001; 24 h: p = 0.003; 48 h: p = 0.034; 72 h: p = 0.005). Infants with more severely depressed aEEG patterns had more negative admission BE values. In contrast, neither admission pH nor BE was significantly associated with MRI-defined brain injury severity. Overall mortality was 7.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Admission metabolic derangement, particularly BE, is associated with early electrocortical depression on serial aEEG but not with MRI-defined structural brain injury severity in neonates with HIE treated with TH. These findings support a dissociation between early metabolic acidosis and established structural brain injury and underscore the importance of multimodal prognostic assessment in early clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261450475","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:25:47Z","timestamp":1778675147000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissociation between early metabolic acidosis and structural brain injury in neonates with hypoxic\u2013ischemic encephalopathy undergoing therapeutic hypothermia"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-121X","authenticated-orcid":false,"given":"Halil","family":"Aslan","sequence":"first","affiliation":[{"name":"Sanliurfa Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-621X","authenticated-orcid":false,"given":"Fatih","family":"Isleyen","sequence":"additional","affiliation":[{"name":"Sanliurfa Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Gumus","sequence":"additional","affiliation":[{"name":"Bursa City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1627448"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23647"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70080-2"},{"key":"e_1_3_7_7_2","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"1","author":"Jacobs SE","year":"2013","unstructured":"Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; 1: CD003311. https:\/\/doi.org\/10.1002\/14651858.CD003311","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"},{"issue":"8","key":"e_1_3_7_9_2","first-page":"CD013546","article-title":"Amplitude-integrated electroencephalography compared with conventional video-electroencephalography for detection of neonatal seizures","volume":"8","author":"Rakshasbhuvankar AA","year":"2025","unstructured":"Rakshasbhuvankar AA, Nagarajan L, Zhelev Z, et al. Amplitude-integrated electroencephalography compared with conventional video-electroencephalography for detection of neonatal seizures. Cochrane Database Syst Rev 2025; 8(8): CD013546. https:\/\/doi.org\/10.1002\/14651858.CD013546.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3422"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50989"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02510-8"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.05.031"},{"issue":"6","key":"e_1_3_7_14_2","first-page":"e62317","article-title":"Progression of amplitude-integrated electroencephalography and neurological outcomes in neonates with hypoxic-ischemic encephalopathy: a single-institution cohort study in Vietnam","volume":"16","author":"Hua T","year":"2024","unstructured":"Hua T, Nguyen TT, Nguyen TT. Progression of amplitude-integrated electroencephalography and neurological outcomes in neonates with hypoxic-ischemic encephalopathy: a single-institution cohort study in Vietnam. Cureus 2024; 16(6): e62317. https:\/\/doi.org\/10.7759\/cureus.62317","journal-title":"Cureus"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0674-9"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01626-z"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.01.050"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.03.065"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798261450475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19345798261450475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19345798261450475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:26:16Z","timestamp":1779107176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19345798261450475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":17,"alternative-id":["10.1177\/19345798261450475"],"URL":"https:\/\/doi.org\/10.1177\/19345798261450475","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"article-number":"19345798261450475"}}