{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:48:27Z","timestamp":1782463707296,"version":"3.54.5"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115C-198"],"award-info":[{"award-number":["V115C-198"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral blood flow (CBF) is critical for neonatal brain health, and disruption of autoregulation may predispose infants to brain injury. The resistive index (RI) of the anterior cerebral artery (ACA), measured via Doppler ultrasonography, is a widely used non-invasive marker of CBF, but its relationship with vital parameters in critically ill neonates remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study at Taipei Veterans General Hospital from January 2022 to December 2024 included neonates admitted to the NICU with ACA Doppler ultrasonography within 24\u00a0h of birth. RI values were stratified into three groups: low (&lt;0.6), normal (0.6\u20130.8), and high (&gt;0.8). Clinical characteristics, resuscitation needs, Apgar scores, blood gas analyses, and short- and long-term outcomes were compared across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 898 admissions, 386 neonates met the inclusion criteria (mean gestational age 35 \u00b1 4\u00a0weeks, mean birth weight 2382 \u00b1 847\u00a0g), abnormal RI was identified in 25.1% (low RI: 4.1%, high RI: 21.0%). Abnormal RI correlated with significantly lower pH, higher pCO\n                      <jats:sub>2<\/jats:sub>\n                      , lower 5-min Apgar scores, and greater need for delivery room intubation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). After adjusting for gestational age, birth weight, and evaluation timing, low RI remained independently associated with increased risks of systemic hypotension and fluid resuscitation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal ACA RI within 24\u00a0h of birth is associated with cerebral hemodynamic instability in critically ill neonates. Early RI assessment may provide insights into neonatal hemodynamic status and serve as a supplemental clinical indicator for identifying high-risk infants in the NICU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261459420","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:43:02Z","timestamp":1782196982000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early cerebral hemodynamic assessment using resistive index and its correlation with neonatal outcomes"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0669-9480","authenticated-orcid":false,"given":"Ting-An","family":"Hsia","sequence":"first","affiliation":[{"name":"Taipei Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5303-9114","authenticated-orcid":false,"given":"Chia-Sui","family":"Chou","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung University"},{"name":"National Yang Ming Chiao Tung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8832-4811","authenticated-orcid":false,"given":"Wei-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung University"},{"name":"National Yang Ming Chiao Tung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-6538","authenticated-orcid":false,"given":"Pei-Chen","family":"Tsao","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung University"},{"name":"National Yang Ming Chiao Tung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-0082","authenticated-orcid":false,"given":"Yu-Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung University"},{"name":"National Yang Ming Chiao Tung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-0367","authenticated-orcid":false,"given":"Mei-Jy","family":"Jeng","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung University"},{"name":"National Yang Ming Chiao Tung University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_3_6_2_2","first-page":"279","article-title":"Transcranial Doppler: a new stethoscope\u2013voiceover tool for neonatal","volume":"2","author":"Kumar G","year":"2023","unstructured":"Kumar G, Patodia J, Padhan NC, et al. Transcranial Doppler: a new stethoscope\u2013voiceover tool for neonatal. Brain. Newborn 2023; 2: 279\u2013290.","journal-title":"Brain. Newborn"},{"key":"e_1_3_6_3_2","first-page":"121","volume-title":"Fetal and Neonatal Neurology and Neurosurgery","author":"Brackley K","year":"2001","unstructured":"Brackley K, Kilby M, Evans D. Doppler assessment of the fetal and neonatal brain. In: Fetal and Neonatal Neurology and Neurosurgery. 3rd ed. Churchill Livingstone, 2001, pp. 121\u2013137.","edition":"3"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000001069"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.748345"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12307"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0141-6"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200007000-00005"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP279730"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00487.2013"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.7_Spec_No.835"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04969-3"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.169"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00882-x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199206000-00022"},{"issue":"1","key":"e_1_3_6_16_2","first-page":"31","article-title":"Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review","volume":"87","author":"Camfferman FA","year":"2020","unstructured":"Camfferman FA, de Goederen R, Govaert P, et al. Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review. 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