{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T12:41:53Z","timestamp":1786279313096,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal jaundice affects most newborns due to immature bilirubin metabolism. Phototherapy continues to be the cornerstone of treatment, having significantly reduced bilirubin-induced neurotoxicity. This study compares continuous and intermittent phototherapy in term neonates with non-hemolytic indirect hyperbilirubinemia to evaluate their relative therapeutic efficacy in achieving effective bilirubin reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective randomized controlled trial was conducted in the Neonatal Intensive Care Unit of a tertiary care medical university in North India between August 2023 and July 2025. Term neonates (gestational age 37\u201342\u00a0weeks, birth weight \u22652500\u00a0g) with non-hemolytic indirect hyperbilirubinemia requiring phototherapy, as per American Academy of Pediatrics guidelines, were enrolled. A total of 150 eligible infants were randomized in equal numbers to receive either continuous phototherapy or intermittent phototherapy (3\u00a0h on\/3\u00a0h off). All participants received standardized double-surface LED phototherapy with an irradiance of \u226530\u00a0\u03bcW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      \/nm within a wavelength range of 460\u2013490\u00a0nm. Infants were repositioned hourly, and exclusive breastfeeding was actively supported. Total serum bilirubin levels were monitored at 12-h intervals until the predefined discontinuation criteria were met.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). Mean baseline TSB was similar (16.07 \u00b1 2.67 vs 15.46 \u00b1 3.04\u00a0mg\/dL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.190). Unadjusted bilirubin reduction at 12\u00a0h and 24\u00a0h did not differ significantly. After adjustment, TSB at 12\u00a0h was comparable (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.418), but higher in the continuous group at 24\u00a0h (mean difference 0.68\u00a0mg\/dL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). The total phototherapy exposure time was shorter with intermittent therapy (13.75 \u00b1 1.18 vs 18.15 \u00b1 1.56\u00a0h;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001). Rebound hyperbilirubinemia and adverse events were similar between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intermittent phototherapy was as effective as continuous phototherapy in reducing bilirubin levels in term neonates with non-hemolytic indirect hyperbilirubinemia requiring treatment, while reducing total phototherapy exposure time and potentially facilitating feeding, mother\u2013infant bonding, and more resource-efficient family-centered care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261475688","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:32:14Z","timestamp":1786149134000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic efficacy of intermittent versus continuous phototherapy in term neonates with hyperbilirubinemia: A randomized controlled trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-5694","authenticated-orcid":false,"given":"D.","family":"Kumar","sequence":"first","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-5979","authenticated-orcid":false,"given":"D.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-4832","authenticated-orcid":false,"given":"R.","family":"Chand","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9317-2796","authenticated-orcid":false,"given":"R.","family":"Nivethaashree","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-6755","authenticated-orcid":false,"given":"S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2717-599X","authenticated-orcid":false,"given":"D.","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8382-5618","authenticated-orcid":false,"given":"D.","family":"Sankhwar","sequence":"additional","affiliation":[{"name":"Uttar Pradesh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17933-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000105"},{"key":"e_1_3_3_4_2","volume-title":"Physiology, Bilirubin. 2022 Sep 12","author":"Kalakonda A","year":"2025","unstructured":"Kalakonda A, Jenkins BA, John S, StatPearls [Internet]. Physiology, Bilirubin. 2022 Sep 12. StatPearls Publishing, 2025. PMID: 29261920."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.12.010"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15126"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"CD008168","article-title":"Intermittent phototherapy versus continuous phototherapy for neonatal jaundice","volume":"3","author":"Gottimukkala SB","year":"2023","unstructured":"Gottimukkala SB, Lobo L, Gautham KS, et al. Intermittent phototherapy versus continuous phototherapy for neonatal jaundice. 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