{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:20:15Z","timestamp":1787768415942,"version":"build-2784847793"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal hypoglycemia is a common, potentially serious postnatal metabolic disorder. This study evaluated the efficacy and safety of a single dose of 40% buccal dextrose gel versus standard care for achieving early euglycemia in at-risk neonates with a documented low baseline blood glucose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective randomized controlled trial was conducted at the Neonatal Intensive Care Unit, Minia University Hospital, Egypt (March-November 2024). Clinically stable, asymptomatic at-risk neonates (gestational age \u226534\u00a0weeks) with a documented low baseline blood glucose (below the maturity-specific operational threshold: &lt;45\u00a0mg\/dL for asymptomatic late-preterm\/term infants and &lt;30\u00a0mg\/dL for preterm infants in the first 48\u00a0h) were randomized 1:1 to standard care alone or standard care plus a single 40% dextrose gel dose (0.5\u00a0mL\/kg, buccal). The primary outcome was euglycemia (blood glucose \u226545\u00a0mg\/dL) at 120\u00a0min, analyzed by intention-to-treat; infants requiring rescue intravenous dextrose before 120 minutes were counted as treatment failures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 120 screened neonates, 100 were randomized (50\/group). By intention-to-treat, euglycemia at 120 minutes occurred in 82.0% (41\/50) of the dextrose gel group versus 64.0% (32\/50) of controls (absolute risk difference 18.0%, 95% CI 1.0-35.0; relative risk 1.28, 95% CI 1.00-1.64; number needed to treat = 6), a difference of borderline statistical significance (Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      p = 0.043; Fisher\u2019s exact\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.070). A secondary complete-case analysis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 90) showed a larger effect (91.1% vs 71.1%) but is potentially biased by exclusion of early treatment failures. Intravenous dextrose use during the study was numerically lower with gel (22.0% [11\/50] vs 36.0% [18\/50]; relative risk 0.61, 95% CI 0.32-1.16) but was not statistically significant. No intervention-related adverse events were observed during the 120-min study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single dose of 40% buccal dextrose gel improved early euglycemia in at-risk neonates by intention-to-treat analysis, with no intervention-related adverse events observed during the 120-min study period. These single-center findings are consistent with existing evidence and support further evaluation of buccal dextrose gel as a non-invasive first-line therapy, rather than establishing broad implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19345798261483257","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:26:32Z","timestamp":1787556392000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-dose 40% buccal dextrose gel for treatment of neonatal hypoglycemia: A randomized controlled trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1716-3899","authenticated-orcid":false,"given":"Nagwa Mohamed Sabry","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Minia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya Rabie","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Minia Health Insurance Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeha Abdalla","family":"Sayed","sequence":"additional","affiliation":[{"name":"Minia University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3851"},{"key":"e_1_3_8_3_2","volume-title":"StatPearls [Internet]","author":"Abramowski A","year":"2025","unstructured":"Abramowski A, Ward R, Hamdan AH. Neonatal hypoglycemia. In: StatPearls [Internet]. StatPearls Publishing, 2025."},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504909"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10071220"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01700-7"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.022"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61645-1"},{"key":"e_1_3_8_9_2","first-page":"51","article-title":"Randomized trial of neonatal hypoglycemia prevention with oral dextrose gel (hPOD study)","volume":"190","author":"Harding JE","year":"2017","unstructured":"Harding JE, Hegarty JE, Crowther CA, et al. Randomized trial of neonatal hypoglycemia prevention with oral dextrose gel (hPOD study). 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Oral dextrose gel and breastfeeding support to prevent neonatal hypoglycemia: a randomized controlled trial. Neonatology 2021; 118(5): 518\u2013525.","journal-title":"Neonatology"},{"issue":"8","key":"e_1_3_8_14_2","first-page":"924","article-title":"Dextrose gel protocol in infants at risk for neonatal hypoglycemia","volume":"57","author":"Makker K","year":"2018","unstructured":"Makker K, Alissa R, Bhola S, et al. Dextrose gel protocol in infants at risk for neonatal hypoglycemia. Clin Pediatr (Phila) 2018; 57(8): 924\u2013931.","journal-title":"Clin Pediatr (Phila)"},{"issue":"1","key":"e_1_3_8_15_2","first-page":"538","article-title":"Neonatal hypoglycaemia and body proportionality in small-for-gestational-age newborns","volume":"22","author":"Smits I","year":"2022","unstructured":"Smits I, Nollet L, Iliescu D, et al. Neonatal hypoglycaemia and body proportionality in small-for-gestational-age newborns. 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