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They have a high incidence rate and currently lack specific curative methods. Trigger point injection therapy is the most popular clinical approach, focusing primarily on these trigger points. Injectable drugs like glucose, normal saline, local anesthetics, botulinum toxin type A, steroid preparations, and platelet-rich plasma are available for this purpose. This treatment is advantageous due to its low cost and minimally invasive nature, showing promising results in early clinical use. However, the lack of consensus on the optimal injectable substance presents a significant challenge in clinical practice. This article reviews the progress in clinical research on trigger point injection therapy and drug efficacy, along with precautions for drug administration in managing myofascial pain syndrome. 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