{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:04:13Z","timestamp":1784160253751,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"abstract":"<jats:p>\n                    Successful osseointegration is crucial for dental implant stability, yet it remains challenging due to adverse local microenvironments, particularly infection and inflammation. While carbon monoxide (CO) has been recognized as a promising gaseous signaling molecule with diverse therapeutic properties, its clinical application faces significant limitations due to dose control challenges. To address this issue, we developed a polyetheretherketone (PEEK)-based photo-responsive implant system with surface-immobilized manganese carbonyl nanocrystals, enabling precisely controlled near-infrared light-triggered CO release. The system demonstrated efficient photoresponsiveness, achieving 13.83\u2009\u00b1\u20091.16 \u03bcM CO release within 10 min under optimal illumination conditions.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    studies revealed that low-dose CO significantly enhanced bone marrow mesenchymal stem cell osteogenic differentiation with upregulated expression of key markers, including Runx2, ALP, and OCN. In a rat femoral defect model, implants with controlled CO release exhibited significantly improved osseointegration. Comprehensive biosafety assessments confirmed the system\u2019s excellent biocompatibility without detectable organ toxicity. This research provides compelling evidence for controlled low-dose CO as an innovative strategy to enhance osseointegration, offering new possibilities for dental and orthopedic implant development, particularly for challenging clinical scenarios with compromised bone healing.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Impact Statement<\/jats:title>\n                    <jats:p>This study introduces a novel approach for improving implant osseointegration through controlled carbon monoxide delivery, potentially offering a new strategy for enhancing the success rate of dental implant procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19373341251383864","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T01:03:26Z","timestamp":1759194206000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential of Low-Dose Carbon Monoxide in Promoting Osseointegration"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3372-0727","authenticated-orcid":false,"given":"Jiahe","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China."},{"name":"National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China."},{"name":"National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China."},{"name":"National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China."},{"name":"National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2025.105612"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.11.018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018593403126"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164693"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104778"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000142364.85911.0e"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123444"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01153"},{"key":"e_1_3_3_11_2","first-page":"30","article-title":"Recent advances in carbon monoxide-releasing nanomaterials","volume":"37","author":"Ning X","year":"2024","unstructured":"Ning X, , Zhu X, , Wang Y, et al. Recent advances in carbon monoxide-releasing nanomaterials. 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