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With an aging population, there is a need to develop innovative, nonsurgical strategies for treating defects, fractures, and other osteochondral disorders. Bone implants require surgical intervention, carry a risk of complications, are expensive, and do not always provide comfort to the patient. Alternatively, stimulation of bone regeneration using synthetic peptides is a promising and less invasive option in the treatment of trauma, orthopedics, craniofacial surgery, and dentistry. In the present study, we evaluated the biological effects of two peptides: the novel peptide UG27 and CDP4 derived from the protein Cpne7\u00a0(Copine 7), on the activity of adipose tissue-derived mesenchymal stem cells. Using labeling, differentiation, and imaging methods, we demonstrated the effect of UG27 on viability, biomineralization, extracellular matrix, and calcium salt growth in osteocytes. The peptides were immunologically safe and stimulated cell migration without showing any cytotoxic effects. The peptide, UG27, has an active connection with the biomaterial and is a promising compound in bone injury therapies.<\/jats:p>","DOI":"10.1177\/19373341251398049","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:06:04Z","timestamp":1768982764000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cpne7 Peptides Enhance the Osteogenic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells"],"prefix":"10.1177","author":[{"given":"Agata","family":"Tymi\u0144ska","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Skoniecka","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Karska","sequence":"additional","affiliation":[{"name":"Department of Biomedical Chemistry, Faculty of Chemistry, University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Czerwiec","sequence":"additional","affiliation":[{"name":"Department of Clinical Anatomy, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kutryb-Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kondej","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Zieli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Transplant Surgery and General Surgery, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Gurzawska-Comis","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health, Aarhus University, Aarhus C, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr M.","family":"Skowron","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Rodziewicz-Motowid\u0142o","sequence":"additional","affiliation":[{"name":"Department of Biomedical Chemistry, Faculty of Chemistry, University of Gda\u0144sk, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Piku\u0142a","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gda\u0144sk, Gda\u0144sk, Poland."},{"name":"Department of Biochemistry, University of Physical Education and Sport, Gda\u0144sk, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02772-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-023-1971-4"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20251847"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136869"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.869422"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241303818"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.004"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202312.2277.v1"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12020313"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050406"},{"issue":"11","key":"e_1_3_5_12_2","first-page":"1618","article-title":"Expressing osteogenic growth peptide in the rabbit bone mesenchymal stem cells increased alkaline phosphatase activity and enhanced the collagen accumulation","volume":"18","author":"An G","year":"2014","unstructured":"An G, , Xue Z, , Zhang B, et al. 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