{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:47:10Z","timestamp":1791730030032,"version":"4.3.4"},"reference-count":87,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Expanding the liver donor pool increasingly depends on extended criteria donors (ECD), including older individuals and those after circulatory death. However, ECD grafts are more susceptible to ischemia-reperfusion injury. Normothermic machine perfusion (NMP) offers a promising solution to preserve the metabolic activity of liver grafts and to assess the graft quality at the same time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We used a standardized rat NMP model to examine the combined effects of donor age and donation after cardiac death on graft viability. Following circulatory arrest and 30 min of warm ischemia, livers from young (3-month-old) and older (12-month-old) Sprague-Dawley rats underwent either 3 or 6 h of NMP (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6\/group). We assessed functional parameters during NMP, metabolic markers, histological injury, and performed proteomic analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All grafts remained metabolically active, with lactate clearance and bile production observed across all groups. While older livers exhibited a more acidotic perfusate pH, younger livers showed significantly higher transaminase release. Histological analysis revealed significantly increased necrosis in older livers after prolonged perfusion. Proteomic profiling identified age- and perfusion time-dependent shifts in pathways related to mitochondrial damage, oxidative stress, and immune activation. Notably, these molecular signs of injury were not consistently reflected in conventional viability markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights how donor age and warm ischemia impact the quality of ECD liver grafts. Histological and molecular assessment during NMP may lead to tailored interventions to improve the quality of such grafts, which is not well reflected by conventional parameters. Our findings support the role of NMP in expanding the utilization of ECD grafts amid organ shortages and an aging donor population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19373341261419492","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:10:01Z","timestamp":1772089801000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Donor Age and Prolonged Warm Ischemia in Normothermic Machine Perfusion of Rat Livers"],"prefix":"10.1177","author":[{"given":"Anna Sophia","family":"Pietsch","sequence":"first","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Boerger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Padoan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian Alexander","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph MGV","family":"Gassner","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Klein","sequence":"additional","affiliation":[{"name":"Center for Regenerative Therapies, Berlin Institute of Health, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene A.","family":"B\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Pathology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pathology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Horst","sequence":"additional","affiliation":[{"name":"Department of Pathology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Iske","sequence":"additional","affiliation":[{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC), Berlin, Germany."},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl H.","family":"Hillebrandt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Krenzien","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor M.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael","family":"Raschzok","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Moosburner","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte, Campus Virchow-Klinikum, Experimental Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"BIH Academy, Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Foundation EI. Statistics report library. 2024. Available from: https:\/\/statistics.eurotransplant.org [Last accessed: May27 2024]."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000183973.49899.b1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24160"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-019-0801-z"},{"key":"e_1_3_3_6_2","unstructured":"United Nations DoEaSA Population Division. World population prospects 2024. 2024. Available from: https:\/\/population.un.org\/wpp\/ [Last accessed: August28 2024]."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.01.025"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.05.014"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02560.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12403"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1199-7432"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002127"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24316"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24865"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.12.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001207"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.01.061"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000181282.14050.11"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01961-x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199205000-00001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0047-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-02014-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.04.031"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/transplantology3020018"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25291"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-018-0178-9"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006491"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2021.10.007"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25362"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2023.0014"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25360"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2024.0048"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235635"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199306000-00011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199112000-00008"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120247"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu684"},{"key":"e_1_3_3_40_2","unstructured":"Yu G. enrichplot: Visualization of functional enrichment result. R package; 2023. Available from: https:\/\/yulab-smu.top\/contribution-knowledge-mining\/"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202500280"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.07.034"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.2.2004664"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.7754\/clin.lab.2012.120630"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24401"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3727\/000000006783982386"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199602150-00012"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21361"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050064"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(96)80253-4"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.10.004"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9346-7"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2003.11679472"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(89)91632-x"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715769109105223"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1991.260.3.G355"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114656"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1994.1140"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1991.261.4.G602"},{"issue":"1","key":"e_1_3_3_62_2","first-page":"9","article-title":"Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury","volume":"43","author":"Liu P","year":"1994","unstructured":"Liu P, , Vonderfecht SL, , Fisher MA, et al. Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury. Circ Shock, 1994; 43(1):9\u201317.","journal-title":"Circ Shock"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.4.377"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.15.2253850"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90191-0"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080211"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.033"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00342.2002"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(02)00867-5"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.23027"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.22074"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.11.009"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.07.061"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00418.x"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90205-h"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.01.013"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21001"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1615\/critreveukargeneexpr.v4.i1.10"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5483"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17062"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01453-06"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr143"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.4.C1286"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3070099"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.24046"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10028"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/16699.7680"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103258"}],"container-title":["Tissue Engineering Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19373341261419492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19373341261419492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19373341261419492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:18:27Z","timestamp":1791728307000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19373341261419492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":87,"alternative-id":["10.1177\/19373341261419492"],"URL":"https:\/\/doi.org\/10.1177\/19373341261419492","relation":{},"ISSN":["1937-3341","1937-335X"],"issn-type":[{"value":"1937-3341","type":"print"},{"value":"1937-335X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"article-number":"19373341261419492"}}