{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:13:27Z","timestamp":1783779207093,"version":"3.55.0"},"reference-count":99,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Bone regeneration presents a significant clinical challenge due to the complex interplay between biological processes and the local mechanical environment. While polymeric scaffolds are widely utilized for their tunable physicochemical properties, traditional designs often fail to replicate the dynamic mechanical cues required for optimal tissue remodeling. This review critically examines the mechanobiological design of bioinspired polymeric scaffolds. We first categorize native bone mechanics and the role of mechanical stimuli\u2014such as stiffness, fluid shear, and stability\u2014in regulating the fracture healing cascade. We then bridge these biological principles with advanced fabrication strategies, analyzing how natural, synthetic, and composite polymers can be engineered to mimic the hierarchical stiffness and bioactivity of native bone. Furthermore, we discuss the role of computational modeling (e.g., Finite Element Analysis) in predicting scaffold performance and highlight emerging technologies, including 4D printing and piezoelectric scaffolds, which offer time-dependent and mechano-electrical adaptability. Finally, we address current barriers to clinical translation and propose future directions for mechanically adaptive systems that actively guide regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19373368261460324","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:12:49Z","timestamp":1783602769000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanobiological Design of Bioinspired Polymeric Scaffolds for Bone Regeneration"],"prefix":"10.1177","author":[{"given":"Shengyu","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China."},{"name":"Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China."},{"name":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, California, USA."},{"name":"UCLA Molecular Biology Institute, Los Angeles, California, USA."},{"name":"Department of Orthopaedic Surgery, UCLA David Geffen School of Medicine, Los Angeles, California, USA."},{"name":"Greater Los Angeles VA Healthcare System, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China."},{"name":"Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China."},{"name":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihui","family":"Ding","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China."},{"name":"Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China."},{"name":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, California, USA."},{"name":"UCLA Molecular Biology Institute, Los Angeles, California, USA."},{"name":"Department of Orthopaedic Surgery, UCLA David Geffen School of Medicine, Los Angeles, California, USA."},{"name":"Greater Los Angeles VA Healthcare System, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4963-5897","authenticated-orcid":false,"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China."},{"name":"Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China."},{"name":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-062117-121139"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102846"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100741"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00474"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0228"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac098"},{"key":"e_1_3_2_8_1","volume-title":"Fracture Healing Overview.","author":"Sheen JR","year":"2024","unstructured":"7.Sheen JR, , Mabrouk A, , Garla VV. 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