{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:10:17Z","timestamp":1790151017002,"version":"4.0.1"},"reference-count":86,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Xiaoshuai Wang","award":["2023A1515110748"],"award-info":[{"award-number":["2023A1515110748"]}]},{"name":"Xiaoshuai Wang","award":["2026A1515011955"],"award-info":[{"award-number":["2026A1515011955"]}]},{"name":"Xiaoshuai Wang","award":["YM202505"],"award-info":[{"award-number":["YM202505"]}]},{"name":"Jia Li","award":["2024A1515011794"],"award-info":[{"award-number":["2024A1515011794"]}]},{"name":"Jia Li","award":["2026A1515010382"],"award-info":[{"award-number":["2026A1515010382"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"abstract":"<jats:p>\n                    Muscle organoids and Organs-on-Chips (OoCs) have emerged as advanced strategies in regenerative medicine and preclinical investigation for muscular diseases. Here, we aim to conduct a comprehensive bibliometric analysis to reveal the global research trends and their evolution in these fields. We retrieved studies on muscle organoids and OoCs published between 2010 and 2025 were retrieved from the Web of Science Core Collection (WoSCC), Scopus, and PubMed databases. Quantitative mapping of publication trends, academic impact, and research hotspots was conducted using R-bibliometrix, VOSviewer, and CiteSpace. A total of 2,083 articles (cardiac,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 990; smooth,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 921; and skeletal,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 261, subgroups are nonexclusive categories) were included. Global publications have expanded rapidly since 2016, achieving an average annual growth rate of 26.0% and peaking in 2025. The United States and China emerged as leading countries in both publication and citation numbers, and Harvard University took the lead among different institutions. Thematic analysis revealed a developmental trajectory evolving from fundamental material engineering (e.g., biosensors) toward functional validation (e.g., drug screening) and sophisticated microenvironment reconstruction (e.g., vascularization and barrier functions). Furthermore, multidimensional metrics suggested a synchronized pattern of academic impact and developmental focus across all three muscle types. This bibliometric analysis reveals a thematic evolution in research priorities, moving beyond generic microfluidic design to addressing systemic tissue engineering bottlenecks, specifically perfusable vascularization, neuromuscular innervation, and multilineage maturation. These findings offer a bibliometric overview that can inform future efforts toward platform standardization, high-throughput screening, and clinical translation for muscular diseases.\n                  <\/jats:p>","DOI":"10.1177\/19373368261486378","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:32:12Z","timestamp":1789968732000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscle Organoids and Organs-on-Chips: A 15-Year Global Bibliometric Perspective"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2883-5062","authenticated-orcid":false,"given":"Zhongxu","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China."},{"name":"School of Pharmaceutical Sciences, Southern Medical University, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojian","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-4984","authenticated-orcid":false,"given":"Liangbin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China."},{"name":"School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong Alan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1384","authenticated-orcid":false,"given":"Xiaoshuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China."},{"name":"School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_3_7_2_1","volume-title":"Cardiac Muscle. In: StatPearls [Internet].","author":"Ripa R","year":"2023","unstructured":"1.Ripa R, , George T, , Shumway KR, et al. Physiology, Cardiac Muscle. In: StatPearls [Internet]. StatPearls Publishing: Treasure Island (FL); 2023."},{"key":"e_1_3_7_3_1","volume-title":"StatPearls","author":"Hafen BB","year":"2023","unstructured":"2.Hafen BB, , Burns B. Physiology, Smooth Muscle. In: StatPearls. StatPearls Publishing: Treasure: Island (FL); 2023."},{"key":"e_1_3_7_4_1","volume-title":"StatPearls","author":"McCuller C","year":"2023","unstructured":"3.McCuller C, , Jessu R, , Callahan AL. Physiology, Skeletal Muscle. In: StatPearls. 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