{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:10:08Z","timestamp":1790784608216,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"abstract":"<jats:p>\n                    Regenerative medicine faces a systemic crisis from a fundamental technological mismatch. The goal is to engineer vascularized tissues, yet prevailing bioprinting paradigms are inadequate. Dominant additive techniques have a resolution limit (\u223c150\u2013200 \u00b5m) and layer artifacts, far exceeding capillary diameters (5\u20137 \u00b5m) and native ECM scale. We argue that refining these methods is a dead end, ignoring the need for submicron (&lt;1 \u00b5m) fidelity. This analysis critically evaluates volumetric alternatives for simultaneous 3D solidification. Within this impasse, we posit that pulsed holographic photopolymerization offers a viable theoretical pathway for instant fabrication of complex, submicron \u201chistionic scaffolds.\u201d A recent breakthrough introduced digital incoherent synthesis of holographic light fields, achieving millimeter-scale fabrication within 0.6 s at 11\u201319 \u00b5m resolution\u2014the first practical implementation approaching medical-grade requirements. However, it still falls short of true submicron fidelity and lacks multimaterial capability. Acoustic holographic bioprinting, despite its potential, is fundamentally limited by acoustic diffraction, achieving only &gt;100 \u00b5m resolution in biomaterials. Achieving the target medical resolution of 0.1\u20130.2 \u00b5m would require gigahertz frequencies, causing catastrophic signal attenuation and making the method unsuitable for volumetric tissue engineering. The emerging linear volumetric method of xolography represents another promising, though currently limited (\u223c5 \u00b5m), direction. The field is also crowded with other technologically complex but flawed trends\u2014like endoscopic\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    printing or advanced robotic extrusion\u2014that simulate progress by repackaging methods with unsuitable resolution, diverting crucial resources. We further propose a novel two-stage paradigm using a prepolymerization \u201cmorphogenetic matrix\u201d to solve the multimaterial problem. The primary impediment is no longer just physics but a critical deficit in funding for fundamental research, exacerbated by the dominance of short-term, simulacral projects. Therefore, advancing beyond this impasse requires a rigorous conceptual shift and a recommitment to foundational science.\n                  <\/jats:p>","DOI":"10.1177\/19373368261491564","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:08:38Z","timestamp":1790669318000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Diffraction Limits: Volumetric Photopolymerization as a Pathway for Medical-Grade Tissue Engineering"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-1859","authenticated-orcid":false,"given":"Alexander","family":"Yu. Pulver","sequence":"first","affiliation":[{"name":"N. N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"A. Pulver","sequence":"additional","affiliation":[{"name":"N. N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation."},{"name":"Voronezh State Technical University, Voronezh, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"E. Tokmachev","sequence":"additional","affiliation":[{"name":"N. N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov","family":"N. Antakova","sequence":"additional","affiliation":[{"name":"N. N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"A. Emelianova","sequence":"additional","affiliation":[{"name":"Voronezh State Technical University, Voronezh, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimma","family":"A. Poltavtseva","sequence":"additional","affiliation":[{"name":"Clinical Immunology Laboratory, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health, Moscow, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44340-024-00003-w"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.37489\/2949-1924-0075"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50923-8"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-026-10114-5"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19755"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf6182"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4866390"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2509652122"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/adb89a"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64154-y"},{"issue":"2","key":"e_1_3_2_12_1","first-page":"12","article-title":"Modern 3D bioengineering: Barriers and limitations on the path to clinical application [Sovremennaya 3D-bioinzheneriya: Bar\u2019ery i ogranicheniya na puti k klinicheskomu primeneniyu]","volume":"24","author":"Emelyanova MA","year":"2025","unstructured":"11.Emelyanova MA, , Pulver NA, , Pulver AY, et al. Modern 3D bioengineering: Barriers and limitations on the path to clinical application [Sovremennaya 3D-bioinzheneriya: Bar\u2019ery i ogranicheniya na puti k klinicheskomu primeneniyu]. Syst Anal Manage Biomed Syst [Sistemnyy Analiz i Upravlenie v Biomeditsinskikh Sistemakh] 2025;24(2):12; doi: 10.36622\/1682-6523.2025.24.2.013","journal-title":"Syst Anal Manage Biomed Syst [Sistemnyy Analiz i Upravlenie v Biomeditsinskikh Sistemakh]"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-3029-7"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501052"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202400162"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-021-01665-2"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54504-7"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.12.021"}],"container-title":["Tissue Engineering Part B: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19373368261491564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19373368261491564","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19373368261491564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:46:13Z","timestamp":1790783173000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19373368261491564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":17,"alternative-id":["10.1177\/19373368261491564"],"URL":"https:\/\/doi.org\/10.1177\/19373368261491564","relation":{},"ISSN":["1937-3368","1937-3376"],"issn-type":[{"value":"1937-3368","type":"print"},{"value":"1937-3376","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"19373368261491564"}}