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Physical exercise has been postulated as an auspicious strategy to counteract age-related disorders preventing premature mortality. However, the effects of chronic exercise training on 1,25-dihydroxyvitamin D [1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D] is unclear. This 12-week randomized controlled trial aimed to investigate the effects of different training modalities on 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D in healthy sedentary adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>\n                      Exercise training will increase 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D in the study cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Randomized controlled clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Level 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 89 healthy sedentary adults (53% women; 53.5 \u00b1 4.9 years old) were enrolled in the FIT-AGEING study. The participants were randomized to (1) a control group (no exercise), (2) physical activity recommendation from the World Health Organization (PAR group), (3) high-intensity interval training (HIIT group), and (4) HIIT adding whole-body electromyostimulation training (HIIT + EMS). 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D plasma levels were measured using a DiaSorin Liaison immunochemiluminometric analyzer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with the control group, 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D increased in PAR (\u0394 = 10.99 \u00b1 3.44 pg\/mL; P = 0.01), HIIT (\u0394 = 11.63 \u00b1 3.51 pg\/mL; P = 0.009), and HIIT + EMS groups (\u0394 = 14.01 \u00b1 3.59 pg\/mL; P = 0.001) without statistical differences between them (all Ps &gt; 0.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In summary, the results show that a 12-week exercise intervention produced an increment of 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D independently of age, sex, and exercise modality in healthy sedentary adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>\n                      The implementation of physical exercise could be considered a strategy not only aiming to reverse the seasonal decrease of 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D in winter explained by low sunlight exposure but also for obtaining subsequent increases of this hormone even in these a priori adverse conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19417381211050033","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T12:07:23Z","timestamp":1634299643000},"page":"518-526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Exercise Training on 1,25(OH)\n                    <sub>2<\/sub>\n                    D Levels: The FIT-AGEING Randomized Controlled Trial"],"prefix":"10.1177","volume":"14","author":[{"given":"Alejandro","family":"De-la-O","sequence":"first","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Jurado-Fasoli","sequence":"additional","affiliation":[{"name":"EFFECTS-262 Research Group, Department of 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