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The prediction and management of neurologic complications of IE are not easily approached algorithmically, and the impact they have on timing and ability to surgically repair or replace the affected valve often requires a painstaking evaluation and joint effort across multiple medical disciplines in order to achieve the best possible outcome. Although specific recommendations are always tailored to the individual patient, there are some guiding principles that can be used to help direct the decision-making process. Herein, we review the pathophysiology, epidemiology, manifestations, and diagnosis of neurological complications of IE and further consider the impact they have on clinical decision making.<\/jats:p>","DOI":"10.1177\/1941874414537077","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T03:22:25Z","timestamp":1401333745000},"page":"213-222","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":97,"title":["Neurologic Complications in Infective Endocarditis"],"prefix":"10.1177","volume":"4","author":[{"given":"Nicholas A.","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Matiello","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"issue":"8","key":"e_1_3_2_2_2","first-page":"785","article-title":"Infective endocarditis","volume":"369","author":"Hoen B","year":"2013","unstructured":"Hoen B, Duval X. 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