{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:52Z","timestamp":1787019352518,"version":"build-2736575974"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Neurohospitalist"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Wernicke-Korsakoff syndrome (WKS) is a triad of ophthalmoplegia, ataxia and memory deficits due to thiamine insufficiency resulting from under- or untreated Wernicke\u2019s encephalopathy (WE), which may be associated with hyperemesis gravidarum (HEG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We present a case of a 36-year-old Filipino woman in her first trimester with HEG, along with the WKS triad and abnormal hyperintense signals in the bilateral thalami and midbrain, left occipital lobe, periaqueductal gray matter and pontine periventricular areas. Neurologic deficits partially improved but persisted despite intravenous thiamine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence review:<\/jats:title>\n                    <jats:p>A review of current treatments for WE, and the prevention and neurocognitive recovery of WKS was done. The beneficial effects of thiamine for acute WKS are supported by several case reports and clinical experience. Evidence from one randomized controlled trial wherein thiamine was given in various doses for treating WE or preventing WKS in an alcohol-dependent population is limited by methodological issues. Rehabilitation and pharmacotherapy for neurocognitive recovery seems promising, but they have inadequate evidentiary support. More robust studies on multi-modal strategies are warranted to facilitate the neurocognitive recovery of patients with WKS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1941874420953027","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T06:03:26Z","timestamp":1599199406000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Wernicke-Korsakoff Syndrome in Hyperemesis Gravidarum: A Case Report and Literature Review"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-3302","authenticated-orcid":false,"given":"Gerald T.","family":"Pagaling","sequence":"first","affiliation":[{"name":"Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian I.","family":"Espiritu","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"},{"name":"Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Froilan D.","family":"Leochico","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida Margarette D.","family":"Andal","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle Anne R.","family":"Blasco","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie Anne C.","family":"Bagnas","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Matthew D.","family":"Pasco","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"bibr1-1941874420953027","volume-title":"Adams and Victor\u2019s Principles of Neurology","author":"Ropper AH","year":"2019","edition":"11"},{"key":"bibr2-1941874420953027","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.51"},{"key":"bibr3-1941874420953027","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S130078"},{"key":"bibr4-1941874420953027","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70104-7"},{"key":"bibr5-1941874420953027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.10.010"},{"key":"bibr6-1941874420953027","doi-asserted-by":"crossref","unstructured":"Greenwood BYJ, Love ER, Pratt E. 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