{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:52:23Z","timestamp":1777877543129,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Neurohospitalist"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Meningovascular neurosyphilis is a common cause of stroke in young adults, particularly when HIV co-infection is present. Contemporary screening for neurosyphilis relies on invasive testing. High resolution vessel wall imaging (HR-VW) is an emerging non-invasive tool to detect intracranial vessel wall inflammation. We report a case of multifocal acute cerebral infarctions from meningovascular neurosyphillis in which HR-VWI was instrumental in leading to the etiological diagnosis. A 32-year-old man with history of untreated HIV and polysubstance abuse presented with sudden onset vertigo. CT angiogram of the head and neck showed non-dominant left extracranial vertebral artery occlusion in the V1 segment, and multifocal areas of stenoses in V2 through V4 segments. Non-contrast brain MRI demonstrated multiple small acute infarcts in the left cerebellum, left brachium pontis, medulla and occipital lobe. Rapid plasma reagin was reactive. 3D whole-brain HR-VWI revealed concentric vessel wall contrast enhancement in the left V4 segment, suggestive of inflammation. This HR-VWI finding prompted further investigation with cerebrospinal fluid analysis that revealed reactive fluorescent treponemal antibody absorption test. The patient received high-dose intravenous Penicillin G, was restarted on highly active antiretroviral therapy, and remained neurologically stable to-date. With high spatial resolution and signal-to-noise ratio, HR-VWI allows for visualization of vessel wall inflammation in co-morbid HIV and neurosyphilis.<\/jats:p>","DOI":"10.1177\/19418744211000524","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T11:41:21Z","timestamp":1615808481000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Clinical Utility of High-Resolution Vessel Wall Imaging in Screening for Meningovascular Neurosyphilis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-4504","authenticated-orcid":false,"given":"Mohammad N.","family":"Kayyali","sequence":"first","affiliation":[{"name":"Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Momii","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA"},{"name":"Radiology and Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana M.","family":"Dumitrascu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"bibr1-19418744211000524","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4893"},{"key":"bibr2-19418744211000524","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26201"},{"key":"bibr3-19418744211000524","unstructured":"Sexually Transmitted Infections Prevalence, Incidence, and Cost Estimates in the United States [online]. Accessed February 2021. https:\/\/www.cdc.gov\/std\/statistics\/prevalence-incidence-cost-2020.htm"},{"key":"bibr4-19418744211000524","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-009-0019-1"},{"key":"bibr5-19418744211000524","volume":"1","author":"Numao A","year":"2014","journal-title":"Eur J Case Rep Intern Med"},{"key":"bibr6-19418744211000524","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000274"},{"key":"bibr7-19418744211000524","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000198"}],"container-title":["The Neurohospitalist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744211000524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19418744211000524","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744211000524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:54:18Z","timestamp":1777589658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19418744211000524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/19418744211000524"],"URL":"https:\/\/doi.org\/10.1177\/19418744211000524","relation":{},"ISSN":["1941-8744","1941-8752"],"issn-type":[{"value":"1941-8744","type":"print"},{"value":"1941-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]}}}