{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:53:25Z","timestamp":1777877605827,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Neurohospitalist"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Bupropion is an atypical antidepressant agent approved for treating major depressive disorders and prescribed for smoking cessation, attention deficit hyperactive disorder (ADHD), and sexual dysfunction. In a few cases, bupropion was associated with myoclonus. We present a case of a 58-year-old male, a heavy smoker seeking smoking cessation, was prescribed bupropion 150\u00a0mg twice daily. The subject doubled the dosage without medical advice. After 3 days of the increased dosage, he started to experience abnormal movements in his upper limbs associated with diffuse facial twitching. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Bupropion was discontinued, and clonazepam was initiated. The subject fully recovered within 24 hours. To the authors\u2019 knowledge, only 8 cases of bupropion-induced myoclonus were reported in the literature. Bupropion discontinuation was the most common management. All individuals except 2 cases fully recovered after bupropion withdrawal. The mechanism of bupropion is probably associated with the serotoninergic pathway.<\/jats:p>","DOI":"10.1177\/19418744231173283","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T12:41:22Z","timestamp":1682426482000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Bupropion-Induced Myoclonus: Case Report and Review of the Literature"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-7335","authenticated-orcid":false,"given":"Asad","family":"Riaz","sequence":"first","affiliation":[{"name":"Pakistan Medical Complex, Rahim Yar Khan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-5911","authenticated-orcid":false,"given":"Hossam Tharwat","family":"Ali","sequence":"additional","affiliation":[{"name":"Qena Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Allahham","sequence":"additional","affiliation":[{"name":"College of Medicine, Sulaiman Alrajhi University, Al-Qassim, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Leticia","family":"Fornari Caprara","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamir Pitton","family":"Rissardo","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"bibr1-19418744231173283","volume-title":"Global Health Data Exchange (GHDx)","author":"Institute of Health Metrics and Evaluation"},{"key":"bibr2-19418744231173283","doi-asserted-by":"publisher","DOI":"10.4103\/AOMD.AOMD_35_19"},{"key":"bibr3-19418744231173283","doi-asserted-by":"publisher","DOI":"10.46747\/CFP.6710743"},{"key":"bibr4-19418744231173283","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.V06N0403"},{"key":"bibr5-19418744231173283","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0302"},{"key":"bibr6-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000142754.46045.8c"},{"key":"bibr7-19418744231173283","doi-asserted-by":"publisher","DOI":"10.7556\/JOM_2007_10.0001"},{"key":"bibr8-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1111\/ADB.13218"},{"key":"bibr9-19418744231173283","unstructured":"Hohler AD, Hartmann JE. A novel case of bupropion induced palatal and limb myoclonus: Hypothesis on the mechanism of action. 7th International Congress of Parkinson\u2019s Disease and Movement Disorders. 2016;17:5-6. Copenhagen, Denmark."},{"key":"bibr10-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23140"},{"key":"bibr11-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.04.002"},{"issue":"15","key":"bibr12-19418744231173283","doi-asserted-by":"crossref","DOI":"10.1212\/01.wnl.0000326213.89576.0e","volume":"96","author":"Goodman M","year":"2021","journal-title":"Neurology"},{"key":"bibr13-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11111708"},{"key":"bibr14-19418744231173283","doi-asserted-by":"publisher","DOI":"10.9734\/ijmpcr\/2015\/14703"},{"key":"bibr15-19418744231173283","doi-asserted-by":"publisher","DOI":"10.1177\/0009922817737082"}],"container-title":["The Neurohospitalist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744231173283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19418744231173283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744231173283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:56:25Z","timestamp":1777589785000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19418744231173283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1177\/19418744231173283"],"URL":"https:\/\/doi.org\/10.1177\/19418744231173283","relation":{},"ISSN":["1941-8744","1941-8752"],"issn-type":[{"value":"1941-8744","type":"print"},{"value":"1941-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]}}}