{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:53:41Z","timestamp":1777877621716,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Neurohospitalist"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Increased intracranial pressure due to cerebral edema is a medical emergency in which 23.4% sodium chloride (23.4% NaCl) may be a lifesaving intervention. Currently, safety data is limited on slow IV push (IVP) administration. The purpose of this study was to evaluate the safety of IVP administration of 23.4% NaCl and determine the number of infusion-related adverse events (IRAEs) compared to slow IV infusion (SIV) administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of patients who received a dose of 23.4% NaCl at the (removed institution) from January 2015 to June 2020 as either SIV over 30 minutes or IVP over 2-5 minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 81 patients, 55 in the IVP group and 26 in the SIV group, were included in the analysis. There was a significantly faster time from order entry to dose completion (IVP 25 [13,58] vs SIV 73 [55,113] minutes, P &lt; .001). There was no difference in IRAEs between the groups (IVP 17 [31%] vs SIV 6 [23%], P = .466). Hypotension was most common (IVP 13 [24%] vs SIV 5 [19%], P = .656) followed by bradycardia (IVP 6 [11%] vs SIV 1 [4%], P = .291). There were no extravasations reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, among a cohort of patients with cerebral edema, we found no difference in the incidence of IRAEs between SIV and IVP administration of 23.4% NaCl, and found a faster time to complete administration fssor the latter. In emergent scenarios where time may impact neurologic function, 23.4% NaCl administered IVP may be an alternative to SIV administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19418744231216851","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:12:30Z","timestamp":1701054750000},"page":"122-128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Safety of Slow IV Push Versus Slow IV Infusion Administration of 23.4% Sodium Chloride"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-7291","authenticated-orcid":false,"given":"Olivia","family":"Iskaros","sequence":"first","affiliation":[{"name":"New York University Langone Health, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Arnouk","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Merchan","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"bibr1-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00959-7"},{"key":"bibr2-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.05986.x"},{"key":"bibr3-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000175726.08903.0A"},{"key":"bibr4-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020982379"},{"key":"bibr5-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017701220"},{"key":"bibr6-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9676-2"},{"key":"bibr7-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304042.05557.60"},{"key":"bibr8-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-013-9907-1"},{"key":"bibr9-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9574-z"},{"key":"bibr10-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000359533.16214.04"},{"key":"bibr11-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199806000-00038"},{"issue":"4","key":"bibr12-19418744231216851","first-page":"113","volume":"1","author":"Valentino AK","year":"2008","journal-title":"J Vasc Interv Neurol"},{"key":"bibr13-19418744231216851","volume-title":"Prevent Errors during Emergency Use of Hypertonic Sodium Chloride Solutions","author":"Institute for Safe Medication Practices","year":"2021"},{"key":"bibr14-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.11.002"},{"key":"bibr15-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-022-01604-1"},{"key":"bibr16-19418744231216851","volume-title":"Does the Joint Commission allow Concentrated Electrolytes to Be Stored outside of the Pharmacy in Patient Care Areas? 2017","author":"The Joint Commission","year":"2021"},{"key":"bibr17-19418744231216851","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01248-7"}],"container-title":["The Neurohospitalist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744231216851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19418744231216851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744231216851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:56:54Z","timestamp":1777589814000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19418744231216851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/19418744231216851"],"URL":"https:\/\/doi.org\/10.1177\/19418744231216851","relation":{},"ISSN":["1941-8744","1941-8752"],"issn-type":[{"value":"1941-8744","type":"print"},{"value":"1941-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}