{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:02:29Z","timestamp":1785564149775,"version":"3.56.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH\/NINDS","award":["1K23NS105935-01"],"award-info":[{"award-number":["1K23NS105935-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Neurohospitalist"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>In a retrospective study evaluating the diagnostic approach of definitive neurological infections at a tertiary referral center, we assessed the time to diagnosis from presentation, number of diagnostic tests ordered, and modality of etiologic diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 111 confirmed clinical cases of neurological infections from 2010-2018 were reviewed. Definitive neuroinfectious diagnoses were defined by positive cerebrospinal (CSF) polymerase chain reaction (PCR)\/antigen, CSF culture, CSF antibody, serology, or pathology tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An etiologic diagnosis was determined at an average (SD) of 3.1 (5.9) days after presentation with an average (SD) of 27.7 (15.6) diagnostic tests ordered per workup.<\/jats:p>\n                    <jats:p>\n                      Viral neuro-infections were associated with lower intensive care unit (ICU) admission rates, shorter length of hospitalization, and fewer diagnostic tests ordered, as well as shorter time to definitive diagnosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Longer hospitalizations were associated with immunosuppression status regardless of infectious etiology (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Given the high morbidity and mortality of neuroinfectious disease, specifically meningitis and encephalitis, efficient diagnostic testing is imperative to facilitate the most appropriate clinical course of action with special attention to the specific patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19418744241242957","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:16:15Z","timestamp":1711595775000},"page":"296-300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Time to Confirmed Neuroinfectious Diagnoses: Diagnostic Testing and Resource Allocation"],"prefix":"10.1177","volume":"14","author":[{"given":"Rachelle","family":"Dugue","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center\/New York Presbyterian Hospital (CUIMC\/NYP)"},{"name":"Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-7212","authenticated-orcid":false,"given":"Carla","family":"Kim","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/New York Presbyterian Hospital (CUIMC\/NYP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilasha","family":"Boruah","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/New York Presbyterian Hospital (CUIMC\/NYP)"},{"name":"Case Western Reserve University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Harrigan","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/New York Presbyterian Hospital (CUIMC\/NYP)"},{"name":"New York University Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Sun","sequence":"additional","affiliation":[{"name":"Columbia University Mailman School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-0323","authenticated-orcid":false,"given":"Kiran T.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/New York Presbyterian Hospital (CUIMC\/NYP)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3442"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00480"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.07.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688441"},{"key":"e_1_3_3_6_2","first-page":"314","article-title":"Aseptic and bacterial meningitis: evaluation, treatment, and prevention","volume":"96","author":"Mount HR","year":"2017","unstructured":"Mount HR, Boyle SD. Aseptic and bacterial meningitis: evaluation, treatment, and prevention. Am Fam Physician. 2017;96:314-322.","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/589747"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803396"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0374-y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01143-21"}],"container-title":["The Neurohospitalist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744241242957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19418744241242957","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19418744241242957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:47:17Z","timestamp":1785563237000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19418744241242957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/19418744241242957"],"URL":"https:\/\/doi.org\/10.1177\/19418744241242957","relation":{},"ISSN":["1941-8744","1941-8752"],"issn-type":[{"value":"1941-8744","type":"print"},{"value":"1941-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]}}}