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Poison Control Centers are uniquely qualified to assist the public and health professionals, including school nurses, with poisoning and overdose incidents and are available 24 hours per day. This article is Part 2 of a series of three articles and focuses on poisonings related to substances of abuse and addiction or as a result of social media challenges. Information includes expected clinical effects, potential for serious injury, and a reasonable approach to manage these exposures for the following substances of potential harm: alcohol, caffeine, dextromethorphan, inhalants, marijuana, tobacco, and nicotine replacement therapy. Part 3 of the series will discuss potential environmental hazards specific to the school setting.<\/jats:p>","DOI":"10.1177\/1942602x221100213","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T02:06:25Z","timestamp":1653703585000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Management of Toxicological Emergencies in the School Setting: An Overview for School Nurses Part 2"],"prefix":"10.1177","volume":"37","author":[{"given":"Amy L.","family":"Deitche","sequence":"first","affiliation":[{"name":"Certified Specialist in Poison Information, Illinois Poison Center (Illinois Health and Hospital Association), Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Burda","sequence":"additional","affiliation":[{"name":"Clinical Toxicologist, Illinois Poison Center (Illinois Health and Hospital Association), Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"bibr1-1942602X221100213","first-page":"337","volume-title":"Poisoning and Drug Overdose7th ed","author":"Benowitz N. 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