{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:59:15Z","timestamp":1791478755768,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute respiratory failure (ARF) in bronchiectasis is frequently accompanied by excessive airway secretions. High-flow nasal cannula (HFNC) delivers heated, humidified gas and may improve respiratory mechanics, but quantitatively measured secretion burden during HFNC in bronchiectasis-related ARF is poorly described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a prospective, single-center pilot cohort study in a respiratory intermediate care unit including adults with computed tomography\u2013confirmed bronchiectasis admitted with ARF and treated with HFNC as first-line therapy. The primary outcome was cumulative secretion volume (operationally defined as supervised collection of expectorated sputum, with measures to minimize saliva contamination) during the first 3\u2009days of HFNC exposure. Physiologic variables, gas exchange, dyspnea, and clinical outcomes were assessed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-six subjects were enrolled (median age 67\u2009years, 54% female), predominantly with moderate-to-severe bronchiectasis. Median cumulative secretion volume over 72 h was 510\u2009mL (436\u2013743), and daily secretion volume increased from Day 1 to Day 3 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Breathing frequency, oxygenation, dyspnea (Borg scale), and selected gas-exchange variables changed significantly over time. No subject required escalation to noninvasive ventilation or endotracheal intubation. In-hospital mortality was 11.5% (3\/26), occurring exclusively in subjects with preestablished do-not-intubate directives.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this pilot cohort of bronchiectasis-related ARF, structured quantification of secretion volume during HFNC was feasible and documented a large early secretion burden over 72 h. Given the uncontrolled design, these findings are descriptive and should not be interpreted as evidence of treatment effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19433654261437778","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T17:01:27Z","timestamp":1776963687000},"page":"1095-1101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Airway Secretion Volume and Physiological Effects of High-Flow Nasal Cannula in Acute Respiratory Failure Caused by Bronchiectasis"],"prefix":"10.1177","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-7363","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Colaianni-Alfonso","sequence":"first","affiliation":[{"name":"Mr. Colaianni-Alfonso, Dr. Montiel, Ms. Siroti, and Mr. Castro-Sayat are affiliated with the Respiratory Intermediate Care Unit, Hospital General Agudos Juan A. Fern\u00e1ndez, Ciudad Autonoma de Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Montiel","sequence":"additional","affiliation":[{"name":"Mr. Colaianni-Alfonso, Dr. Montiel, Ms. Siroti, and Mr. Castro-Sayat are affiliated with the Respiratory Intermediate Care Unit, Hospital General Agudos Juan A. Fern\u00e1ndez, Ciudad Autonoma de Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Siroti","sequence":"additional","affiliation":[{"name":"Mr. Colaianni-Alfonso, Dr. Montiel, Ms. Siroti, and Mr. Castro-Sayat are affiliated with the Respiratory Intermediate Care Unit, Hospital General Agudos Juan A. Fern\u00e1ndez, Ciudad Autonoma de Buenos Aires, Argentina."},{"name":"Ms. Siroti is affiliated with the Department of Kinesiology, Hospital del T\u00f3rax Dr. Antonio A. Cetr\u00e1ngolo, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Castro-Sayat","sequence":"additional","affiliation":[{"name":"Mr. Colaianni-Alfonso, Dr. Montiel, Ms. Siroti, and Mr. Castro-Sayat are affiliated with the Respiratory Intermediate Care Unit, Hospital General Agudos Juan A. Fern\u00e1ndez, Ciudad Autonoma de Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Vetrugno","sequence":"additional","affiliation":[{"name":"Prof. Vetrugno is affiliated with the Department of Emergency, Anesthesia and Intensive Care Unit, Tolmezzo Hospital, Health Integrated Agency of Friuli Centrale, Tolmezzo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Crimi","sequence":"additional","affiliation":[{"name":"Prof. Crimi is affiliated with the Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy."},{"name":"Prof. Crimi is affiliated with the Respiratory Medicine Unit, Policlinico \u201cG. Rodolico-San Marco\u201d University Hospital, Catania, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMRA2202819"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000492"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.201208-1518OC"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12931-019-1243-3"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0055-2019"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000300084.67277.90"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00134-009-1743-6"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.828"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00134-020-06312-Y"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01574-2021"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.4187\/RESPCARE.04577"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.RMED.2009.12.016"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972307087190"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00962-2024"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2020.1728736"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.201309-1575OC"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00711-2020"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0161-2019"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.4266\/ACC.2019.00563"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jointm.2024.10.005"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2025.2490715"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S104616"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00769.2021"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19433654261437778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19433654261437778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19433654261437778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:46:54Z","timestamp":1791478014000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19433654261437778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/19433654261437778"],"URL":"https:\/\/doi.org\/10.1177\/19433654261437778","relation":{},"ISSN":["1943-3654","1943-3654"],"issn-type":[{"value":"1943-3654","type":"print"},{"value":"1943-3654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}