{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:39:49Z","timestamp":1787323189228,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Identifying predictors of noninvasive respiratory support failure is crucial to avoid delays in intubation. This study assessed, in a homogeneous group of patients with SARS-CoV-2-related acute hypoxemic respiratory failure (AHRF), the association between outcome and early measured expired tidal volume normalized to predicted body weight (V\n                      <jats:sub>T<\/jats:sub>\n                      <jats:sub>e<\/jats:sub>\n                      \/PBW), a surrogate of lung-distending pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This single-center retrospective study was conducted at a Swiss tertiary-care university hospital. Data were collected from medical records of patients admitted to the ICU between March 2020 and April 2022 for SARS-CoV-2-related AHRF requiring noninvasive respiratory support, with V\n                      <jats:sub>Te<\/jats:sub>\n                      recorded during an early positive pressure session using an oronasal mask and a double-limb circuit. V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW and other potential factors associated with outcome were compared between patients with favorable and unfavorable (intubation and\/or ICU death) outcomes using Fisher\u2019s exact and Mann\u2013Whitney tests. The optimal V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW cutoff associated with unfavorable outcome was identified with the Youden index. Univariate and multivariate analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighty subjects\u00a0were included, 38 (47.5%) with unfavorable outcome. Median V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW was higher in the unfavorable outcome group (9.8 [8.6\u201311.5]\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      8.5 [7.6\u201310.1] mL\/kg PBW,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). In univariate analysis, V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW was associated with outcome (odds ratio [OR]\u00a0= 1.27, 95% CI = 1.06\u20131.57), as were age, gender, Sequential Organ Failure Assessment, SAPS II,\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:msub>\n                              <mml:mrow>\n                                <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                              <\/mml:mrow>\n                              <mml:mrow>\n                                <mml:mrow>\n                                  <mml:msub>\n                                    <mml:mrow>\n                                      <mml:mi mathvariant=\"normal\">pO<\/mml:mi>\n                                    <\/mml:mrow>\n                                    <mml:mrow>\n                                      <mml:mn>2<\/mml:mn>\n                                    <\/mml:mrow>\n                                  <\/mml:msub>\n                                <\/mml:mrow>\n                              <\/mml:mrow>\n                            <\/mml:msub>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      \/\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:msub>\n                              <mml:mrow>\n                                <mml:mi mathvariant=\"normal\">F<\/mml:mi>\n                              <\/mml:mrow>\n                              <mml:mrow>\n                                <mml:mrow>\n                                  <mml:msub>\n                                    <mml:mrow>\n                                      <mml:mi mathvariant=\"normal\">iO<\/mml:mi>\n                                    <\/mml:mrow>\n                                    <mml:mrow>\n                                      <mml:mn>2<\/mml:mn>\n                                    <\/mml:mrow>\n                                  <\/mml:msub>\n                                <\/mml:mrow>\n                              <\/mml:mrow>\n                            <\/mml:msub>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      ratio at admission, and VOX index. The area under the receiver operating characteristic curve for the correlation between V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW and unfavorable outcome was 0.66. Based on the Youden index, the V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW cutoff most strongly associated with the outcome was 8.5\u2009mL\/kg PBW. Nevertheless, because differences across V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW cutoffs were small, this threshold should be considered hypothesis-generating.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW during an early positive-pressure ventilation session was associated with worsening outcomes in subjects\u00a0with SARS-CoV-2-related AHRF. The V\n                      <jats:sub>Te<\/jats:sub>\n                      \/PBW cutoff most strongly associated with unfavorable outcome was 8.5\u2009mL\/kg PBW.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19433654261471319","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:04:16Z","timestamp":1787133856000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tidal Volume Threshold for Noninvasive Respiratory Support Failure in Hypoxemic Respiratory Failure"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2233-9378","authenticated-orcid":false,"given":"Charlotte","family":"Despland","sequence":"first","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Lais","sequence":"additional","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."},{"name":"Dr. Lais is affiliated with Department of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, and Anesthesia, Emergency and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Renaud","sequence":"additional","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cristiani","sequence":"additional","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Daniel","family":"Chiche","sequence":"additional","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Piquilloud","sequence":"additional","affiliation":[{"name":"Ms. Despland, Dr. Lais, Dr. Renaud, Ms. Cristiani, Dr. Chiche, and Dr. Piquilloud are affiliated with Adult Intensive Care Unit, University Hospital of Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06459-2"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-08036-3"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2516087"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07050-7"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3693-5"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02873-4"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-025-03773-z"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666221081042"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05942-6"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122738"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144018"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081CP"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07401-y"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201912-2512OC"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06519-7"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000001379"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000002818"},{"key":"e_1_3_3_19_1","first-page":"650","article-title":"Gentamicin therapy","volume":"8","author":"Devine BJ","year":"1974","unstructured":"18.Devine BJ. 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