{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:29:39Z","timestamp":1777660179751,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Genetic variations of long noncoding RNAs are potential biomarkers for gastric cancer (GC). However, reports on the association between single nucleotide polymorphisms (SNPs) in antisense noncoding RNA in the INK4 locus (\n                      <jats:italic toggle=\"yes\">ANRIL<\/jats:italic>\n                      ) and GC risk are few. This case-control study aimed to evaluate the association between SNPs in\n                      <jats:italic toggle=\"yes\">ANRIL<\/jats:italic>\n                      , GC risk, and subgroups in a Korean population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      The TaqMan genotyping assay of six SNPs in\n                      <jats:italic toggle=\"yes\">ANRIL<\/jats:italic>\n                      was performed in 419 patients with GC and 348 controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After adjusting for age and gender, the following significant associations were identified: rs2157719 in the dominant model (TC+CC vs. TT) with decreased GC risk in the lymph node metastasis (LNM)-negative subgroup (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.045, adjusted odds ratio [AOR] = 0.65, 95% confidence interval [CI] = 0.43\u20130.99); rs1333040 in the recessive model (CC vs. TT+TC) with increased risk in the undifferentiated subgroup (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.032, AOR = 1.92, 95% CI = 1.06\u20133.50); and rs4977574 in the dominant model (AG+GG vs. AA) with decreased risk in the LNM-positive, tumor stage III (A+B+C), and undifferentiated subgroups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.007, AOR = 0.58, 95% CI = 0.39\u20130.86;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.028, AOR = 0.63, 95% CI = 0.42\u20130.95; and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.049, AOR = 0.63, 95% CI = 0.40\u20131.00, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that these SNPs in\n                      <jats:italic toggle=\"yes\">ANRIL<\/jats:italic>\n                      are associated with GC risk and influence GC development. Further studies are needed to confirm our results in different ethnic groups and larger populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265251375929","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:50:39Z","timestamp":1757688639000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Association Between Polymorphisms in lncRNA\n                    <i>ANRIL<\/i>\n                    and Gastric Cancer Susceptibility"],"prefix":"10.1177","volume":"29","author":[{"given":"Sang-Il","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Gyu","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Ae","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chungnam National University College of Medicine, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-4429","authenticated-orcid":false,"given":"Eun-Heui","family":"Jin","sequence":"additional","affiliation":[{"name":"Translational Immunology Institute, Chungnam National University College of Medicine, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Hee","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chungnam National University College of Medicine, Daejeon, Republic of Korea."},{"name":"Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.004"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030537"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1629-3"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.601"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.233"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23110"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv074"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.09.006"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.7"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903103106"},{"key":"e_1_3_7_12_1","first-page":"121","article-title":"Association between lncRNA HULC rs7763881 polymorphism and gastric cancer risk","volume":"13","author":"Hong JH","year":"2020","unstructured":"Hong JH, , Jin EH, , Chang IA, et al. 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