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The condition\u2019s pathology not only involves the digestive system but also can impact various organs and tissues throughout the body. Metabolic syndrome is a clinical syndrome characterized by obesity, insulin resistance, hypertension, and hyperlipidemia. Extensive research suggests a potential association between IBD and metabolic syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To seek biomarkers related to the diagnosis and treatment of IBD and metabolic syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this study, we utilized bioinformatics, integrated transcriptome analysis, and machine learning to develop a diagnostic model for the co-occurrence of IBD and metabolic syndrome. We applied two machine learning algorithms to select relevant features Least Absolute Shrinkage and Selection Operator and Random Forest (RF). Moreover, through external datasets and quantitative real-time polymerase chain reaction (qRT-PCR) experiments, we validated our findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified nine candidate gene-expression-based biomarkers (\n                      <jats:italic toggle=\"yes\">CCR6, CST7, LIMK2, TCF4, THBS3, CARS2, IFI27, LETM1, LOXL1<\/jats:italic>\n                      ) associated with immune and metabolic regulation that exhibited discriminatory potential for IBD complicated by metabolic syndrome. Furthermore, a column chart for diagnosing IBD in metabolic syndrome patients is provided.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study demonstrates that integrated bioinformatics and machine learning approaches can identify transcriptomic signatures associated with IBD and metabolic syndrome, providing candidate biomarkers for further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265261440155","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:13:44Z","timestamp":1776226424000},"page":"107-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and Validation of Transcriptomic Signatures in Inflammatory Bowel Disease with Metabolic Syndrome via Bioinformatics and Machine Learning"],"prefix":"10.1177","volume":"30","author":[{"given":"Yu-zhe","family":"Yin","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-sheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-qing","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-yu","family":"Pei","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-zheng","family":"Xue","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-lin","family":"Ren","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7062-689X","authenticated-orcid":false,"given":"Ying-yue","family":"Sheng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi School of Medicine, Jiangnan University, Wuxi City, Jiangsu Province, China."},{"name":"Jiangnan University, Wuxi City, Jiangsu Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"1","article-title":"LIMK\/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance","volume":"472","author":"Aggelou H","year":"2018","unstructured":"Aggelou H, , Chadla P, , Nikou S, et al. 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