{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:52:49Z","timestamp":1781700769629,"version":"3.54.5"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Open Research Fund Program of the State Key Laboratory of Virology","award":["2024KF003"],"award-info":[{"award-number":["2024KF003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To investigate the associations among protein tyrosine phosphatase (\n                      <jats:italic toggle=\"yes\">PTPN22<\/jats:italic>\n                      ), nucleotide-binding oligomerization domain-like receptor protein 3 (\n                      <jats:italic toggle=\"yes\">NLRP3<\/jats:italic>\n                      ) and genetic susceptibility to psoriasis in the Jiujiang population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 120 psoriasis patients and 90 healthy controls were enrolled. Polymerase chain reaction-based sequencing was performed to determine the distribution of\n                      <jats:italic toggle=\"yes\">PTPN22<\/jats:italic>\n                      rs1310182, rs2488457, and\n                      <jats:italic toggle=\"yes\">NLRP3<\/jats:italic>\n                      rs10754558 genotypes. Logistic regression analysis was conducted to evaluate the associations between the genotypes, alleles, and genetic models of these three loci and psoriasis susceptibility. The associations between these polymorphisms and disease subtypes or severity were also explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      With respect to the\n                      <jats:italic toggle=\"yes\">PTPN22<\/jats:italic>\n                      rs2488457 locus, the GG genotype and G allele were identified as risk factors for psoriasis susceptibility (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.026 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.004, respectively). In the dominant model, carriers of the GG genotype exhibited a significantly higher risk of psoriasis than did those with the GC+CC genotype (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.016). No significant associations were observed between the rs1310182 or rs10754558 polymorphisms and psoriasis susceptibility (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). In addition, none of the three loci were significantly correlated with the disease subtype or severity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      In the Jiujiang population, the GG genotype and G allele of the\n                      <jats:italic toggle=\"yes\">PTPN22<\/jats:italic>\n                      rs2488457 locus may be key factors influencing psoriasis susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265261440160","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:35:21Z","timestamp":1775622921000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <i>PTPN22<\/i>\n                    and\n                    <i>NLRP3<\/i>\n                    Gene Polymorphisms with Psoriasis Susceptibility in a Han Chinese Population"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0626-898X","authenticated-orcid":false,"given":"Jiajia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei 434000, China."},{"name":"Department of Laboratory Medicine, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi 332000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-0825","authenticated-orcid":false,"given":"Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei 434000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei 434000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi 332000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi 332000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei 434000, 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