{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:10:25Z","timestamp":1779358225803,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Behcet\u2019s syndrome (BS) was first described in 1937 as a triad of oral aphthae, genital ulceration, and ocular involvement. It is now recognized as a multisystemic vasculitis that can affect central nervous, gastrointestinal, and cardiovascular systems. Despite extensive research, the etiology of BS remains unclear, and genetic, viral, and environmental factors are thought to contribute to its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the role of interleukin-17 (IL-17) and IL-23 receptor (IL-23R) gene polymorphisms in the etiology of BS and to evaluate their associations with disease activity and clinical features. The IL-23\/IL-17 axis was selected due to its pivotal role in T cell\u2013mediated inflammation and vasculitis, which are key pathogenic mechanisms in BS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was conducted at the Ankara University Faculty of Medicine over a 1-year period. A total of 142 patients with BS aged \u226518 years and 140 healthy controls without known rheumatologic or immunological diseases were included. BS was diagnosed according to the International Study Group criteria for Beh\u00e7et\u2019s disease. Disease activity was assessed using the BS Activity Scale, and patients were classified as having active or inactive disease. Genomic DNA was extracted from peripheral blood samples. IL-17 and IL-23R gene polymorphisms were analyzed using the polymerase chain reaction\u2013restriction fragment length polymorphism method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The IL-17 rs2275913 and rs763780 polymorphisms and the IL-23R rs11209032 polymorphism were evaluated. The frequency of the homozygous AA genotype of the rs11209032 was significantly higher in the BS group than in healthy controls (85.9% vs. 17.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Carriage of the A allele was associated with a markedly increased risk of BS; after adjustment for age and sex, carriers had approximately 16-fold higher odds of disease (adjusted odds ratios [OR] = 16.32, 95% confidence intervals [CI]: 9.76\u201327.12,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). No significant differences were observed between BS patients and controls for the IL-17 polymorphisms. Gene polymorphisms were not associated with specific clinical manifestations. However, in the IL-17 rs763780 polymorphism, inactive patients had a higher frequency of the TT genotype compared with the TC genotype (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03), suggesting a potential role in disease activity rather than susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that IL-17 and IL-23R\u2013related pathways may contribute to the pathogenesis of BS. While the IL-17 variant may be associated with disease activity, the IL-23R rs11209032 polymorphisms show a strong association with disease susceptibility. However, larger studies are needed to confirm these findings and clarify their clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265261447151","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:50:01Z","timestamp":1777553401000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-HLA Genetic Polymorphisms of Interleukin-17 and Interleukin-23 Receptor in Behcet\u2019s Syndrome"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-7639","authenticated-orcid":false,"given":"Serap","family":"Boz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Boz","sequence":"additional","affiliation":[{"name":"Department of Emergency, Faculty of Medicine, Hacettepe University Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamir","family":"Cerci","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turker","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Ankara University, Ankara, Turkey."},{"name":"Department of Molecular Biology, Faculty of Science, Ankara University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Olmez","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14479"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01339-9"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.794874"},{"key":"e_1_3_3_5_1","first-page":"1152","article-title":"\u00dcber rezidivierende, aphthose, durch ein virus verursachte Geschw\u00fcre am Mund, am Auge und an den Genitalien","volume":"105","author":"Beh\u00e7et H","year":"1937","unstructured":"Beh\u00e7et H. \u00dcber rezidivierende, aphthose, durch ein virus verursachte Geschw\u00fcre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 1937;105:1152\u20131157.","journal-title":"Dermatol Wochenschr"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1390"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.002"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.114"},{"issue":"4","key":"e_1_3_3_9_1","first-page":"S28","article-title":"Behcet\u2019s syndrome activity score (BSAS): A new disease activity assessment tool, composed of patient-derived measures only, is strongly correlated with the Behcet\u2019s Disease Current Activity Form (BDCAF)","volume":"26","author":"Forbess CSC","year":"2008","unstructured":"Forbess CSC, , Yazici Y. Behcet\u2019s syndrome activity score (BSAS): A new disease activity assessment tool, composed of patient-derived measures only, is strongly correlated with the Behcet\u2019s Disease Current Activity Form (BDCAF). 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Patient-driven assessment of disease activity in Beh\u00e7et\u2019s syndrome: Cross-cultural adaptation, reliability and validity of the Turkish version of the Beh\u00e7et\u2019s Syndrome Activity Score. Clin Exp Rheumatol 2013;31(3 Suppl 77):77\u201383.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.12.005"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19450265261447151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19450265261447151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19450265261447151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:49:08Z","timestamp":1779356948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19450265261447151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1177\/19450265261447151"],"URL":"https:\/\/doi.org\/10.1177\/19450265261447151","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}