{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:28:10Z","timestamp":1786681690010,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute heart failure (AHF) is a prevalent and life-threatening condition that is associated with high morbidity and mortality, particularly in adults. MicroRNAs (miRNAs) have been identified as potential biomarkers in various cardiovascular diseases. Specifically, miR-302b-3p and miR-103 have demonstrated potential as biomarkers in heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aims to investigate the diagnostic and prognostic potential of circulating miR-302b-3p and miR-103 in AHF among Egyptian adults and the association between these miRNAs and NT-proBNP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study involved 95 participants, comprising 45 Egyptian adults diagnosed with AHF and 50 age- and gender-matched healthy controls. Circulating levels of miR-302b-3p and miR-103 were measured using qRT-PCR, while NT-ProBNP levels were determined via enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The expression of miR-302b-3p was significantly decreased in patients with AHF compared with healthy controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). The levels of this miRNA showed a significant negative correlation with NT-proBNP levels (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.78,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.013). Lower levels of miR-302b-3p and increased NT-ProBNP levels correlated with more severe prognosis, including higher rates of hospitalization and 1-year mortality in patients with AHF (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NT-ProBNP and miR-302b-3p serve as a promising biomarker for the diagnosis and prognosis of AHF in Egyptian adults that can further guide health care professionals for risk stratification and therapeutic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265261470709","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:58:08Z","timestamp":1785232688000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Expression Profile of microRNA Genes and NT-proBNP as Possible Predictors of One-Year Mortality in Egyptian Adults with Acute Heart Failure: A Prospective Biomarker Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Haidy","family":"Magdy","sequence":"first","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-0424","authenticated-orcid":false,"given":"Radwa M.","family":"Abdel Halim","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May M.","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Abou El","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad","family":"Mosaad","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"7","key":"e_1_3_3_2_1","first-page":"11","article-title":"Study of the role of plasma NTproBNP in the diagnosis of heart failure","volume":"70","author":"Athavale B","year":"2022","unstructured":"Athavale B, , Pathak J. Study of the role of plasma NTproBNP in the diagnosis of heart failure. J Assoc Physicians India 2022;70(7):11\u201312.","journal-title":"J Assoc Physicians India"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3036"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01001-5"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029110"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft078"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14153"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04981-7"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa065"},{"issue":"9","key":"e_1_3_3_10_1","first-page":"1155","article-title":"Natriuretic peptides for heart failure diagnosis and management","volume":"73","author":"Januzzi JL","year":"2019","unstructured":"Januzzi JL, , Ahmad T, , Bhalla V. Natriuretic peptides for heart failure diagnosis and management. J Am Coll Cardiol 2019;73(9):1155\u20131178.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14643"},{"key":"e_1_3_3_12_1","first-page":"2234","article-title":"Differential expression of circulating microRNAs in patients with acute heart failure","volume":"22","author":"Kaneto CM","year":"2018","unstructured":"Kaneto CM, , Nascimento JHM, , Moreira LFP, et al. Differential expression of circulating microRNAs in patients with acute heart failure. Eur Rev Med Pharmacol Sci 2018;22:2234\u20132243.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.06.055"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.418"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.950"},{"issue":"15","key":"e_1_3_3_18_1","first-page":"8274","article-title":"miR-103 and its emerging role in cardiac oxidative stress and metabolic dysfunction","volume":"23","author":"Wang X","year":"2022","unstructured":"Wang X, , Chen Z, , Jiang L. miR-103 and its emerging role in cardiac oxidative stress and metabolic dysfunction. Int J Mol Sci 2022;23(15):8274.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.01.013"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/arm91050034"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19450265261470709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19450265261470709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19450265261470709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:49:05Z","timestamp":1786679345000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19450265261470709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1177\/19450265261470709"],"URL":"https:\/\/doi.org\/10.1177\/19450265261470709","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}