{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:10Z","timestamp":1792787710833,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fasa University of Medical Sciences","id":[{"id":"https:\/\/ror.org\/05bh0zx16","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Brucellosis is recognized as one of the most widespread zoonotic diseases, caused by facultative intracellular coccobacilli of the genus\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      . Interleukin-27 (IL-27) is a pleiotropic cytokine that serves a critical role in the development of immunity against\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      . IL-27 single nucleotide polymorphisms (SNPs) may influence susceptibility to brucellosis by altering the expression and\/or function of this cytokine. This study sought to examine the potential association between IL-27 genetic polymorphisms and brucellosis susceptibility among Iranian individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study comprised 207 patients diagnosed with brucellosis and 82 healthy livestock workers as controls matched geographically to the patients\u2019 population. IL-27 SNPs at positions \u2212964 A\/G, 2905 T\/G, and 4730 T\/C were genotyped and then evaluated through case\u2013control comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Genotype analysis revealed a significantly higher frequency of the TG genotype at rs17855750 in controls compared to patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0002). Conversely, the TT genotype at rs17855750 and the CC genotype at rs181206 were more frequent in patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.012 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.026, respectively). Furthermore, specific haplotypes (AGT and GGT) and haplogenotypes (ATT\/AGT, GTC\/GGT, and ATT\/GTT) showed a significantly different distribution between the groups, being more prevalent in controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      This study provides evidence for an association between IL-27 gene variants and brucellosis susceptibility, reinforcing the role of host genetics in\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      infection. These findings not only enhance our understanding of brucellosis pathogenesis but also pave the way for genetic-based risk assessment and the development of novel therapeutic strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19450265261491082","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:48:56Z","timestamp":1790268536000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Interleukin-27 Gene Variants with Susceptibility to Brucellosis Among Iranian Population: A Case\u2013Control Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Mehdi","family":"Kalani","sequence":"first","affiliation":[{"name":"Department of Immunology, Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfane","family":"Fattah","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Asaei","sequence":"additional","affiliation":[{"name":"Department of Immunology, Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maral","family":"Choopanizadeh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Kalani","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnosis, Farzanegan Lab, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Saffar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences, Fasa University of Medical Sciences, Fasa, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojat","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Motahari Clinic, Shiraz University of Medical Sciences, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-5012","authenticated-orcid":false,"given":"Ali","family":"Moravej","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran."},{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences, Fasa University of Medical Sciences, Fasa, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Montaseri","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534259231178594"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14030265"},{"issue":"3","key":"e_1_3_3_4_1","first-page":"158","article-title":"Interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis","volume":"10","author":"Asaei S","year":"2013","unstructured":"Asaei S, , Rasouli M, , Moravej A. Interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis. Iran J Immunol 2013;10(3):158\u2013166.","journal-title":"Iran J Immunol"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.04.008"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00207-4"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801162"},{"issue":"3","key":"e_1_3_3_8_1","first-page":"47","article-title":"Brucellosis in Islamic republic of Iran","volume":"3","author":"Esmaeili H","year":"2015","unstructured":"Esmaeili H. Brucellosis in Islamic republic of Iran. 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