{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:47:05Z","timestamp":1792388825939,"version":"4.4.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood eosinophil and basophil levels have recently been considered for the purpose of endotyping chronic rhinosinusitis with nasal polyps (CRSwNP). Histologically, eosinophilic-type CRSwNPs have been associated with high recurrence rates after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study was the first to compare blood eosinophil and basophil counts in eosinophilic-type CRSwNP patients before and after endoscopic sinus surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study concerned 79 consecutive patients with histologically confirmed eosinophilic-type CRSwNP treated with endoscopic sinus surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant drop in mean blood eosinophil counts and percentages occurred from before to after endoscopic sinus surgery in the cohort as a whole. Mean blood eosinophil counts and percentages were also reduced after surgery in the subcohorts of CRSwNP patients with (i) asthma, (ii) aspirin-exacerbated respiratory disease (AERD), and (iii) no allergy. Although blood eosinophil and basophil counts correlated directly before and after surgery, a statistical reduction in blood basophil counts and percentages after surgery emerged only in the subcohort of nonallergic CRSwNP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endoscopic sinus surgery can clear polyps, remove inflammatory tissue, and reduce inflammatory cytokine levels. Consistently with the biological mechanism described, endoscopic sinus surgery could coincide with a reduction in blood eosinophils in eosinophilic-type CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892418768590","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T07:35:52Z","timestamp":1528184152000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Blood Eosinophil and Basophil Values Before and After Surgery for Eosinophilic-type Sinonasal Polyps"],"prefix":"10.1177","volume":"32","author":[{"given":"Giuseppe","family":"Brescia","sequence":"first","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience, Padova University, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Parrino","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience, Padova University, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"bibr1-1945892418768590","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.402"},{"key":"bibr2-1945892418768590","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2018.39.4101"},{"key":"bibr3-1945892418768590","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1092"},{"key":"bibr4-1945892418768590","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.271"},{"key":"bibr5-1945892418768590","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4405"},{"key":"bibr6-1945892418768590","first-page":"MC08","volume":"11","author":"Sreeparvathi A","year":"2017","journal-title":"J Clin Diagn 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