{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:44:56Z","timestamp":1790282696303,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic chronic rhinosinusitis (eCRS) is linked with skewed T-helper 2 or immunoglobulin E (IgE)-mediated allergic responses, with differing diagnosis, prognosis, and management to non-eCRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The association between biomarkers and eCRS was investigated to assess the predictors of eCRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study of adult patients with chronic rhinosinusitis (CRS) undergoing endoscopic sinus surgery was conducted. eCRS was defined by histopathological assessment showing &gt;10 eosinophils\/high-power field on sinus mucosal biopsy. Blood tests were performed preoperatively and assessed for a full blood count including eosinophils and a white cell count (WCC) as well as biochemical markers of inflammation and atopy including Immunoglobulin E (IgE), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and ImmunoCAP testing for serum-specific IgE. Comparisons between eCRS and non-eCRS patients were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      345 patients (48.1% female, age 48.72\u2009\u00b1\u200915.06 years) were recruited, with 206 (59.7%) identified as eCRS, 41% with asthma and 47% CRS with nasal polyps. eCRS patients were more likely to have asthma ( P\u2009&lt;\u2009.01) and nasal polyps ( P\u2009&lt;\u2009.01). Blood eosinophils were significantly elevated in eCRS (0.42\u00b10.34 vs 0.17\u00b10.13\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, P\u2009&lt;\u2009.01) as were eosinophils as a ratio of WCC (6.21\u2009\u00b1\u20094.48 vs 2.55\u2009\u00b1\u20091.84, P\u2009&lt;\u2009.01). ESR was decreased when compared with non-eCRS (8.1\u00b17.87 vs 10.65\u00b111.91, P = .03). Receiver operating characteristic curve analysis predicted high tissue eosinophilia at blood eosinophil levels above 0.24\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L (sensitivity 70.9%, specificity 78.4%, area under the curve [AUC]: 0.792, P &lt; .01). eCRS was predicted at eosinophil above 4.27% of total WCC (sensitivity 64.1%, specificity 88.5%, AUC 0.797; P\u2009&lt;\u2009.01; positive predictive value 89.2%, negative predictive value 62.4%, positive likelihood ratio 5.57, and diagnostic odds ratio 13.71). There was no significant association among WCC, CRP, IgE, or ImmunoCAP testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      eCRS is associated with elevated blood eosinophils (&gt;0.24\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L), eosinophil ratio (&gt;4.27% of total WCC), and lower ESR when compared with non-eCRS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892418779451","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T07:52:05Z","timestamp":1528098725000},"page":"252-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":102,"title":["Systemic Predictors of Eosinophilic Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"32","author":[{"given":"Jacqueline","family":"Ho","sequence":"first","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales, Sydney, Australia"},{"name":"St Vincent\u2019s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneeza W.","family":"Hamizan","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales, Sydney, Australia"},{"name":"Department of Otorhinolaryngology\u2009\u2013\u2009Head & Neck Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rimmer","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales, Sydney, Australia"},{"name":"Woolcock Institute, University of Sydney, Sydney, Australia"},{"name":"Faculty of Medicine, Notre Dame University, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Sewell","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia"},{"name":"Immunology Division, Garvan Institute of Medical Research, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales, Sydney, Australia"},{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, 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