{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:36:48Z","timestamp":1788565008901,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the national natural science foundation of China","doi-asserted-by":"crossref","award":["81630023, 81420108009, 81400444 and 81470678"],"award-info":[{"award-number":["81630023, 81420108009, 81400444 and 81470678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University","award":["20181045"],"award-info":[{"award-number":["20181045"]}]},{"name":"the Program for Changjiang Scholars and Innovative Research Team","award":["IRT13082"],"award-info":[{"award-number":["IRT13082"]}]},{"name":"the national key R&D program of China","award":["2016YFC20160905200"],"award-info":[{"award-number":["2016YFC20160905200"]}]},{"name":"Beijing Municipal Administration of Hospitals\u2019 Youth Programme","award":["QML20150202"],"award-info":[{"award-number":["QML20150202"]}]},{"name":"Beijing Municipal Administration of Hospitals\u2019 Mission Plan","award":["SML20150203"],"award-info":[{"award-number":["SML20150203"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Corticosteroids are considered the most effective medication to control chronic rhinosinusitis with nasal polyps (CRSwNP); however, the studies of systemic corticosteroids in this field are relatively few and meta-analyses are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to systematically review the efficacy and safety of systemic corticosteroids for patients with CRSwNP via meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from relevant and appropriate randomized controlled trials (RCTs) of systemic corticosteroids for patients with CRSwNP from PubMed, MEDLINE, Ovid, Embase, the Cochrane Central Register of Controlled Trials, and Google Scholar. Efficacy was assessed based on clinical outcomes, while safety was assessed based on adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 337 relevant publications were identified, of which 7 RCTs including 414 participants were included in the meta-analysis. Compared to placebos or nonsteroid treatments, systemic corticosteroids significantly improved nasal obstruction scores standardized mean difference (SMD \u22122.81; 95% confidence interval [CI], \u22124.68 to \u22120.95; P\u2009=\u2009.003), reduced the nasal polyp size (SMD \u22124.76; 95% CI, \u22126.99 to \u22122.52; P\u2009&lt;\u2009.0001), and improved peak nasal inspiratory flow (PNIF) (SMD 42.39; 95% CI, 28.95 to 55.84; P\u2009&lt;\u2009.00001). The high-dose (more than or equal to 50 mg\/day prednisone) and low-dose subgroups (less than 50 mg\/day prednisone) experienced similar benefits. However, insomnia and gastrointestinal disturbances were noted more frequently in patients treated with high doses of prednisone. Other AEs were infrequent and were not significantly different between the subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic corticosteroids provide significant improvements in nasal symptoms and PNIF as well as a reduction in nasal polyp size for patients with CRSwNP. Prednisone doses less than 50 mg\/day were recommended when the efficacy of oral corticosteroids in CRSwNP was balanced against potential adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892419851312","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T04:56:08Z","timestamp":1559019368000},"page":"567-576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of Short-Term Systemic Corticosteroid Therapy in Chronic Rhinosinusitis With Nasal Polyps: A Meta-Analysis of Randomized Controlled Trials and Systematic Review"],"prefix":"10.1177","volume":"33","author":[{"given":"Yunyun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China"},{"name":"Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"bibr1-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.010"},{"key":"bibr2-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0823-y"},{"key":"bibr3-1945892419851312","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.255"},{"key":"bibr4-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.09.020"},{"key":"bibr5-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21847"},{"key":"bibr6-1945892419851312","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"},{"key":"bibr7-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000205218.37514.0f"},{"key":"bibr8-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.012"},{"key":"bibr9-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.628"},{"key":"bibr10-1945892419851312","first-page":"CD011992","volume":"4","author":"Head K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr11-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0329-5"},{"key":"bibr12-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25352"},{"key":"bibr13-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0061-7"},{"issue":"1","key":"bibr14-1945892419851312","first-page":"8","volume":"44","author":"Alobid I","year":"2006","journal-title":"Rhinology"},{"key":"bibr15-1945892419851312","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin10.140"},{"key":"bibr16-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24330"},{"key":"bibr17-1945892419851312","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-5-201103010-00003"},{"issue":"5","key":"bibr18-1945892419851312","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4193\/Rhino11.140","volume":"49","author":"Kirtsreesakul V","year":"2011","journal-title":"Rhinology"},{"key":"bibr19-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112124"},{"key":"bibr20-1945892419851312","doi-asserted-by":"crossref","unstructured":"Van Zele T, Gevaert P, Holtappels G, et al. Oral steroids and doxycycline: Two different approaches to treat nasal polyps.\n                      J Allergy Clin Immunol\n                      . 2010;125(5):1069\u20131076.","DOI":"10.1016\/j.jaci.2010.02.020"},{"key":"bibr21-1945892419851312","doi-asserted-by":"crossref","unstructured":"Kirtsreesakul V, Wongsritrang K, Ruttanaphol S. Does oral prednisolone increase the efficacy of subsequent nasal steroids in treating nasal polyposis?\n                      Am J Rhinol\n                      . 2012;26(6):455\u2013462.","DOI":"10.2500\/ajra.2012.26.3820"},{"issue":"7","key":"bibr22-1945892419851312","first-page":"CD005232","author":"Martinez-Devesa P","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr23-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21373"},{"key":"bibr24-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.010"},{"key":"bibr25-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31814842f8"},{"key":"bibr26-1945892419851312","first-page":"CD011991","volume":"4","author":"Head K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr27-1945892419851312","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21072"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1945892419851312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1945892419851312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1945892419851312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:36:13Z","timestamp":1777368973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1945892419851312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/1945892419851312"],"URL":"https:\/\/doi.org\/10.1177\/1945892419851312","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]}}}